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E2f7 Gene Detail
Summary
  • Symbol
    E2f7
  • Name
    E2F transcription factor 7
  • Synonyms
    A630014C11Rik, D10Ertd739e, E2F7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289147
    NCBI Gene: 52679
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:110581300-110623245 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 57.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1440 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289147
 protein coding gene Chr10:110580799-110623245 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017716
 protein coding gene Chr10:113108731-113152771 (+)
A/J MGP_AJ_G0017693
 protein coding gene Chr10:108820286-108862723 (+)
AKR/J MGP_AKRJ_G0017655
 protein coding gene Chr10:111992659-112035669 (+)
BALB/cJ MGP_BALBcJ_G0017657
 protein coding gene Chr10:109215935-109262482 (+)
C3H/HeJ MGP_C3HHeJ_G0017482
 protein coding gene Chr10:112119722-112163052 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018114
 protein coding gene Chr10:117024185-117072178 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015793
 protein coding gene Chr10:103658601-103701057 (+)
CAST/EiJ MGP_CASTEiJ_G0017043
 protein coding gene Chr10:112297124-112340668 (+)
CBA/J MGP_CBAJ_G0017451
 protein coding gene Chr10:121574343-121640424 (+)
DBA/2J MGP_DBA2J_G0017556
 protein coding gene Chr10:107947641-107990222 (+)
FVB/NJ MGP_FVBNJ_G0017550
 protein coding gene Chr10:106939437-106990377 (+)
LP/J MGP_LPJ_G0017630
 protein coding gene Chr10:113737913-113786632 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017579
 protein coding gene Chr10:124319192-124364494 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018152
 protein coding gene Chr10:111999866-112047204 (+)
PWK/PhJ MGP_PWKPhJ_G0016825
 protein coding gene Chr10:108030167-108072815 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016615
 protein coding gene Chr10:110776949-110830408 (+)
WSB/EiJ MGP_WSBEiJ_G0017103
 protein coding gene Chr10:112155722-112200422 (+)



Homology
more
  • Human Ortholog
    E2F7, E2F transcription factor 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    E2F7, E2F transcription factor 7
  • Links
    NCBI Gene ID: 144455
    neXtProt AC: NX_Q96AV8
    UniProt: Q96AV8

  • Chr Location
    12q21.2; chr12:77021248-77065569 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    24 phenotypes from multigenic genotypes
    25 phenotype references
Mice homozygous for a knock-out allele develop normally through puberty and survive to old age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    32
  • cDNA Data
    66
  • Literature Summary
    12
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020185 Ensembl Gene Model | MGI Sequence Detail 41946 C57BL/6J ±  kb
transcript ENSMUST00000073781 Ensembl | MGI Sequence Detail 5473 Not Applicable  
polypeptide ENSMUSP00000073453 Ensembl | MGI Sequence Detail 904 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 67
    cDNA 66
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2443849
References
more
  • Summaries
    All 63
    Developmental Gene Expression 12
    Gene Ontology 10
    Phenotypes 25
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:339251 Moreno E, et al., Inhibition of polyploidization in Pten-deficient livers reduces steatosis. Liver Int. 2022 Nov;42(11):2442-2452
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory