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Mettl2 Gene Detail
Summary
  • Symbol
    Mettl2
  • Name
    methyltransferase 2, methylcytidine
  • Synonyms
    2810438F06Rik, C130031G21Rik, D11Ertd768e, PSENIP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289171
    NCBI Gene: 52686
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:105017251-105031220 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 68.61 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    561 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289171
 protein coding gene Chr11:105017251-105031972 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019281
 protein coding gene Chr11:108338817-108353576 (+)
A/J MGP_AJ_G0019249
 protein coding gene Chr11:103707893-103721877 (+)
AKR/J MGP_AKRJ_G0019218
 protein coding gene Chr11:106854680-106868626 (+)
BALB/cJ MGP_BALBcJ_G0019223
 protein coding gene Chr11:104144940-104159100 (+)
C3H/HeJ MGP_C3HHeJ_G0019032
 protein coding gene Chr11:107138170-107152151 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019673
 protein coding gene Chr11:111693405-111708930 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017298
 protein coding gene Chr11:101064024-101078450 (+)
CAST/EiJ MGP_CASTEiJ_G0018586
 protein coding gene Chr11:108183509-108197565 (+)
CBA/J MGP_CBAJ_G0019001
 protein coding gene Chr11:116326553-116340510 (+)
DBA/2J MGP_DBA2J_G0019113
 protein coding gene Chr11:103216786-103230762 (+)
FVB/NJ MGP_FVBNJ_G0019104
 protein coding gene Chr11:102729058-102743022 (+)
LP/J MGP_LPJ_G0019183
 protein coding gene Chr11:108803031-108818494 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019134
 protein coding gene Chr11:115612517-115626496 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019710
 protein coding gene Chr11:107331965-107345937 (+)
PWK/PhJ MGP_PWKPhJ_G0018351
 protein coding gene Chr11:104300118-104314281 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018141
 protein coding gene Chr11:107075372-107089396 (+)
WSB/EiJ MGP_WSBEiJ_G0018636
 protein coding gene Chr11:107293087-107308196 (+)



Homology
more
  • Human Ortholog
    METTL2A, methyltransferase 2A, tRNA N3-cytidine
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL2A, methyltransferase 2A, tRNA N3-cytidine
  • Synonyms
    METTL2
  • Links
    NCBI Gene ID: 339175
    neXtProt AC: NX_Q96IZ6
    UniProt: Q96IZ6

  • Chr Location
    17q23.2; chr17:62423875-62453385 (+)  GRCh38
  • Human Ortholog
    METTL2B, methyltransferase 2B, tRNA N3-cytidine
  • Synonyms
    METL, METTL2, METTL2A, PSENIP1
  • Links
    NCBI Gene ID: 55798
    neXtProt AC: NX_Q6P1Q9
    UniProt: Q6P1Q9

  • Chr Location
    7q32.1; chr7:128476729-128506602 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced 3-methylcytidine (m3C) methyltransferases modification of tRNA.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    123
  • cDNA Data
    13
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020691 Ensembl Gene Model | MGI Sequence Detail 13970 C57BL/6J ±  kb
transcript ENSMUST00000021030 Ensembl | MGI Sequence Detail 1867 Not Applicable  
polypeptide ENSMUSP00000021030 Ensembl | MGI Sequence Detail 389 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010908 tRNA N(3)-methylcytidine methyltransferase METTL2
    (term hierarchy)
  • EC
    2.1.1.-
  • InterPro Domains
    IPR013217 Methyltransferase type 12
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    IPR026113 tRNA N(3)-methylcytidine methyltransferase METTL2/6/8-like
Molecular
Reagents
less
  • All nucleic 17
    Genomic 3
    cDNA 13
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1920002, MGI:2144544, MGI:2442741
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory