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Echdc2 Gene Detail
Summary
  • Symbol
    Echdc2
  • Name
    enoyl Coenzyme A hydratase domain containing 2
  • Synonyms
    1300017C12Rik, 2610009M20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289238
    NCBI Gene: 52430
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:108022634-108036505 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 50.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    558 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289238
 protein coding gene Chr4:108022630-108036505 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028549
 protein coding gene Chr4:108884175-108898020 (+)
A/J MGP_AJ_G0028512
 protein coding gene Chr4:104972042-104985933 (+)
AKR/J MGP_AKRJ_G0028459
 protein coding gene Chr4:107560020-107587570 (+)
BALB/cJ MGP_BALBcJ_G0028531
 protein coding gene Chr4:105172678-105186532 (+)
C3H/HeJ MGP_C3HHeJ_G0028245
 protein coding gene Chr4:108296210-108310065 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028971
 protein coding gene Chr4:112796355-112810946 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026262
 protein coding gene Chr4:100260317-100283404 (+)
CAST/EiJ MGP_CASTEiJ_G0027681
 protein coding gene Chr4:106154688-106169970 (+)
CBA/J MGP_CBAJ_G0028214
 protein coding gene Chr4:116462131-116479554 (+)
DBA/2J MGP_DBA2J_G0028362
 protein coding gene Chr4:104599129-104613047 (+)
FVB/NJ MGP_FVBNJ_G0028330
 protein coding gene Chr4:103464867-103481104 (+)
LP/J MGP_LPJ_G0028463
 protein coding gene Chr4:109087902-109101828 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028356
 protein coding gene Chr4:121707149-121721025 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029007
 protein coding gene Chr4:107806178-107821721 (+)
PWK/PhJ MGP_PWKPhJ_G0027407
 protein coding gene Chr4:102862145-102876637 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027231
 protein coding gene Chr4:105168122-105182518 (+)
WSB/EiJ MGP_WSBEiJ_G0027762
 protein coding gene Chr4:107991404-108005700 (+)



Homology
more
  • Human Ortholog
    ECHDC2, enoyl-CoA hydratase domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ECHDC2, enoyl-CoA hydratase domain containing 2
  • Links
    NCBI Gene ID: 55268
    neXtProt AC: NX_Q86YB7
    UniProt: Q86YB7

  • Chr Location
    1p32.3; chr1:52895910-52927212 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    4 involving Echdc2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    23 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    873
  • Tissues
    110
  • cDNA Data
    95
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028601 Ensembl Gene Model | MGI Sequence Detail 13872 C57BL/6J ±  kb
transcript ENSMUST00000052999 Ensembl | MGI Sequence Detail 1307 Not Applicable  
polypeptide ENSMUSP00000051268 Ensembl | MGI Sequence Detail 296 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000029436 enoyl-CoA hydratase domain-containing protein 2, mitochondrial
    (term hierarchy)
  • InterPro Domains
    IPR029045 ClpP/crotonase-like domain superfamily
    IPR014748 Enoyl-CoA hydratase, C-terminal
    IPR001753 Enoyl-CoA hydratase/isomerase
    IPR018376 Enoyl-CoA hydratase/isomerase, conserved site
Molecular
Reagents
less
  • All nucleic 97
    cDNA 95
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1915695, MGI:1917149
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory