Tbc1d22a MGI Mouse Gene Detail - MGI:1289265 - TBC1 domain family, member 22a

Symbol

Tbc1d22a
Name

TBC1 domain family, member 22a
Synonyms

D15Ertd781e, MGC:28337

Feature Type

protein coding gene
IDs

MGI:1289265
NCBI Gene: 223754
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr15:86098660-86382704 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 40.56 cM
Mapping Data

2 experiments

SNPs within 2kb

6934 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1289265	protein coding gene	Chr15:86095502-86382704 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022203	protein coding gene	Chr15:87176587-87470792 (+)
A/J	MGP_AJ_G0022162	protein coding gene	Chr15:83898408-84182088 (+)
AKR/J	MGP_AKRJ_G0022137	protein coding gene	Chr15:86373819-86667181 (+)
BALB/cJ	MGP_BALBcJ_G0022168	protein coding gene	Chr15:84024068-84306401 (+)
C3H/HeJ	MGP_C3HHeJ_G0021938	protein coding gene	Chr15:86324455-86613347 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022613	protein coding gene	Chr15:90412897-90703946 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020138	protein coding gene	Chr15:80198647-80473402 (+)
CAST/EiJ	MGP_CASTEiJ_G0021460	protein coding gene	Chr15:87147850-87428206 (+)
CBA/J	MGP_CBAJ_G0021905	protein coding gene	Chr15:93458126-93749521 (+)
DBA/2J	MGP_DBA2J_G0022032	protein coding gene	Chr15:83353015-83629823 (+)
FVB/NJ	MGP_FVBNJ_G0022011	protein coding gene	Chr15:82439513-82725117 (+)
LP/J	MGP_LPJ_G0022103	protein coding gene	Chr15:87322598-87627635 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022031	protein coding gene	Chr15:98074970-98361212 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022628	protein coding gene	Chr15:86400420-86682616 (+)
PWK/PhJ	MGP_PWKPhJ_G0021201	protein coding gene	Chr15:83376526-83668433 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021035	protein coding gene	Chr15:86108468-86377582 (+)
WSB/EiJ	MGP_WSBEiJ_G0021509	protein coding gene	Chr15:86878380-87160577 (+)

Human Ortholog

TBC1D22A, TBC1 domain family member 22A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBC1D22A, TBC1 domain family member 22A
Synonyms

C22orf4, HSC79E021
Links

HGNC:1309

NCBI Gene ID: 25771

neXtProt AC: NX_Q8WUA7

UniProt: Q8WUA7
Chr Location

22q13.31; chr22:46762617-47175699 (+) GRCh38

MGI Vertebrate Homology

Tbc1d22a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TBC1D22A
Gene Tree

Tbc1d22a

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References

1 with disease annotations

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

29
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Tbc1d22a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

77

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tbc1d22a

ZFIN tbc1d22a

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All Sequences

79
RefSeq

24
UniProt

2
CCDS

CCDS27729.1

Ensembl

ENSMUSG00000051864 (Evidence)
NCBI Gene

223754

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051864	Ensembl Gene Model \| MGI Sequence Detail	284045	C57BL/6J	± kb
transcript	ENSMUST00000063414	Ensembl \| MGI Sequence Detail	3229	Not Applicable
polypeptide	ENSMUSP00000065721	Ensembl \| MGI Sequence Detail	516	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016106 TBC1 domain family member 22A

(term hierarchy)
InterPro Domains

IPR000195 Rab-GAP-TBC domain

IPR035969 Rab-GAP-TBC domain superfamily

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All nucleic 78

cDNA 77

Primer pair 1

Microarray probesets 4

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MGI:2385024

Summaries

All 60

Diseases 1

Gene Ontology 4

Phenotypes 34
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tbc1d22a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132579	Chr15:86098632-86098656 (+)	-16 bp
Tssr132580	Chr15:86098662-86098673 (+)	8 bp
Tssr4685	Chr15:86118908-86118929 (+)	20,259 bp
Tssr132581	Chr15:86119073-86119086 (+)	20,420 bp
Tssr132582	Chr15:86161837-86161883 (+)	63,200 bp
Tssr132583	Chr15:86209430-86209451 (+)	110,781 bp
Tssr132584	Chr15:86210206-86210215 (+)	111,551 bp
Tssr132585	Chr15:86217973-86217985 (+)	119,319 bp
Tssr132586	Chr15:86218033-86218045 (+)	119,379 bp
Tssr132587	Chr15:86218673-86218687 (+)	120,020 bp
Tssr132588	Chr15:86219177-86219214 (+)	120,536 bp
Tssr132589	Chr15:86299635-86299639 (+)	200,977 bp
Tssr132590	Chr15:86320301-86320308 (+)	221,645 bp
Tssr132591	Chr15:86353200-86353201 (+)	254,541 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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