Zfp410 MGI Mouse Gene Detail - MGI:1289280

Symbol

Zfp410
Name

zinc finger protein 410
Synonyms

D12Ertd748e

Feature Type

protein coding gene
IDs

MGI:1289280
NCBI Gene: 52708
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:84363626-84390497 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.15 cM
Mapping Data

2 experiments

SNPs within 2kb

650 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1289280	protein coding gene	Chr12:84363615-84391213 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019932	protein coding gene	Chr12:85017994-85045817 (+)
A/J	MGP_AJ_G0019889	protein coding gene	Chr12:81795406-81826446 (+)
AKR/J	MGP_AKRJ_G0019865	protein coding gene	Chr12:84014697-84045157 (+)
BALB/cJ	MGP_BALBcJ_G0019869	protein coding gene	Chr12:82126699-82161173 (+)
C3H/HeJ	MGP_C3HHeJ_G0019675	protein coding gene	Chr12:84480120-84509327 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020320	protein coding gene	Chr12:87454980-87487038 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017938	protein coding gene	Chr12:78703791-78730374 (+)
CAST/EiJ	MGP_CASTEiJ_G0019224	protein coding gene	Chr12:79431668-79459185 (+)
CBA/J	MGP_CBAJ_G0019646	protein coding gene	Chr12:90835189-90872046 (+)
DBA/2J	MGP_DBA2J_G0019761	protein coding gene	Chr12:81329375-81356625 (+)
FVB/NJ	MGP_FVBNJ_G0019747	protein coding gene	Chr12:80281379-80308136 (+)
LP/J	MGP_LPJ_G0019833	protein coding gene	Chr12:84895786-84925262 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019786	protein coding gene	Chr12:93749612-93782874 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020354	protein coding gene	Chr12:83610397-83638860 (+)
PWK/PhJ	MGP_PWKPhJ_G0018988	protein coding gene	Chr12:75816020-75843759 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018783	protein coding gene	Chr12:78096819-78128771 (+)
WSB/EiJ	MGP_WSBEiJ_G0019276	protein coding gene	Chr12:84321426-84350831 (+)

Human Ortholog

ZNF410, zinc finger protein 410

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF410, zinc finger protein 410
Synonyms

APA-1, APA1
Links

HGNC:20144

NCBI Gene ID: 57862

neXtProt AC: NX_Q86VK4

UniProt: Q86VK4
Chr Location

14q24.3; chr14:73886617-73932521 (+) GRCh38

MGI Vertebrate Homology

Zfp410 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZNF410
Gene Tree

Zfp410

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

4
Targeted

2
Genomic Mutations

1 involving Zfp410
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display moderately decreased body weight but no gross hematological abnormalities.

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

847
Tissues

138
cDNA Data

96
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase znf410

ZFIN znf410

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All Sequences

101
RefSeq

22
UniProt

7
CCDS

CCDS26042.1, CCDS88368.1, CCDS88369.1

Ensembl

ENSMUSG00000042472 (Evidence)
NCBI Gene

52708

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042472	Ensembl Gene Model \| MGI Sequence Detail	26872	C57BL/6J	± kb
transcript	ENSMUST00000045931	Ensembl \| MGI Sequence Detail	2597	Not Applicable
polypeptide	ENSMUSP00000045550	Ensembl \| MGI Sequence Detail	478	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000017875 zinc finger protein 410

(term hierarchy)
InterPro Domains

IPR050329 GLI C2H2-type zinc-finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 98

cDNA 96

Primer pair 2

Microarray probesets 4

Summaries

All 40

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 8
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:308797 Vinjamur DS, et al., ZNF410 represses fetal globin by singular control of CHD4. Nat Genet. 2021 May;53(5):719-728

TSS for Zfp410:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114335	Chr12:84363604-84363639 (+)	-4 bp
Tssr114336	Chr12:84363865-84363875 (+)	244 bp
Tssr114337	Chr12:84363876-84363921 (+)	273 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24