Zfp622 MGI Mouse Gene Detail - MGI:1289282

Symbol

Zfp622
Name

zinc finger protein 622
Synonyms

1110033B05Rik, D15Ertd806e, ZPR9

Feature Type

protein coding gene
IDs

MGI:1289282
NCBI Gene: 52521
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr15:25984452-25998567 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 9.71 cM
Mapping Data

3 experiments

SNPs within 2kb

410 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1289282	protein coding gene	Chr15:25984452-25998568 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021752	protein coding gene	Chr15:24006905-24021021 (+)
A/J	MGP_AJ_G0021712	protein coding gene	Chr15:23092231-23106347 (+)
AKR/J	MGP_AKRJ_G0021690	protein coding gene	Chr15:23604918-23619032 (+)
BALB/cJ	MGP_BALBcJ_G0021719	protein coding gene	Chr15:23075202-23089318 (+)
C3H/HeJ	MGP_C3HHeJ_G0021495	protein coding gene	Chr15:23645385-23659501 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022158	protein coding gene	Chr15:25033077-25047193 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019698	protein coding gene	Chr15:21406115-21420070 (+)
CAST/EiJ	MGP_CASTEiJ_G0021011	protein coding gene	Chr15:24012215-24034610 (+)
CBA/J	MGP_CBAJ_G0021464	protein coding gene	Chr15:25846007-25860123 (+)
DBA/2J	MGP_DBA2J_G0021588	protein coding gene	Chr15:22863680-22877796 (+)
FVB/NJ	MGP_FVBNJ_G0021566	protein coding gene	Chr15:22423986-22438102 (+)
LP/J	MGP_LPJ_G0021656	protein coding gene	Chr15:23862268-23876384 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021591	protein coding gene	Chr15:28529713-28543829 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022181	protein coding gene	Chr15:23797135-23811247 (+)
PWK/PhJ	MGP_PWKPhJ_G0020754	protein coding gene	Chr15:23007807-23022054 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020592	protein coding gene	Chr15:23616811-23653485 (+)
WSB/EiJ	MGP_WSBEiJ_G0021067	protein coding gene	Chr15:23801290-23815406 (+)

Human Ortholog

ZNF622, zinc finger protein 622

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF622, zinc finger protein 622
Synonyms

ZPR9
Links

HGNC:30958

NCBI Gene ID: 90441

neXtProt AC: NX_Q969S3

UniProt: Q969S3
Chr Location

5p15.1; chr5:16451519-16465800 (-) GRCh38

MGI Vertebrate Homology

Zfp622 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZNF622
Gene Tree

Zfp622

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
1 images
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

5
Targeted

2
Genomic Mutations

2 involving Zfp622
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available

Mice homozygous for a knock-out allele show complete embryonic lethality before implantation. In vitro outgrowth assays show that embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming blastocysts.

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All GO Annotations

24
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

16
cDNA Data

50
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

2
UniProt

4
CCDS

CCDS27400.1

Ensembl

ENSMUSG00000052253 (Evidence)
NCBI Gene

52521

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052253	Ensembl Gene Model \| MGI Sequence Detail	14116	C57BL/6J	± kb
transcript	ENSMUST00000061875	Ensembl \| MGI Sequence Detail	2802	Not Applicable
polypeptide	ENSMUSP00000059678	Ensembl \| MGI Sequence Detail	476	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000018036 cytoplasmic 60S subunit biogenesis factor ZNF622

(term hierarchy)
InterPro Domains

IPR003604 Matrin/U1-C-like, C2H2-type zinc finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

IPR040025 Zinc finger protein 622/Rei1/Reh1

IPR041661 ZN622/Rei1/Reh1, zinc finger C2H2-type

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All nucleic 53

cDNA 51

Primer pair 2

Microarray probesets 7

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MGI:1915924

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zfp622:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130867	Chr15:25984419-25984422 (+)	-31 bp
Tssr130868	Chr15:25984445-25984459 (+)	0 bp
Tssr130869	Chr15:25984469-25984477 (+)	21 bp
Tssr130870	Chr15:25984483-25984537 (+)	58 bp
Tssr130871	Chr15:25984548-25984563 (+)	104 bp
Tssr130872	Chr15:25984566-25984577 (+)	120 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24