F2rl2 MGI Mouse Gene Detail - MGI:1298208 - coagulation factor II thrombin receptor like 2

Symbol

F2rl2
Name

coagulation factor II thrombin receptor like 2
Synonyms

PAR-3, PAR3

Feature Type

protein coding gene
IDs

MGI:1298208
NCBI Gene: 14064
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:95833428-95839276 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 50.38 cM
Mapping Data

4 experiments

SNPs within 2kb

357 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1298208	protein coding gene	Chr13:95833361-95839276 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020845	protein coding gene	Chr13:97185837-97191494 (+)
A/J	MGP_AJ_G0020799	protein coding gene	Chr13:93535728-93541386 (+)
AKR/J	MGP_AKRJ_G0020773	protein coding gene	Chr13:96392081-96397936 (+)
BALB/cJ	MGP_BALBcJ_G0020796	protein coding gene	Chr13:94212791-94218646 (+)
C3H/HeJ	MGP_C3HHeJ_G0020589	protein coding gene	Chr13:96079180-96085035 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021232	protein coding gene	Chr13:100127037-100132923 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018801	protein coding gene	Chr13:89363679-89369549 (+)
CAST/EiJ	MGP_CASTEiJ_G0020108	protein coding gene	Chr13:95388271-95393932 (+)
CBA/J	MGP_CBAJ_G0020548	protein coding gene	Chr13:104103758-104109613 (+)
DBA/2J	MGP_DBA2J_G0020673	protein coding gene	Chr13:93311640-93317495 (+)
FVB/NJ	MGP_FVBNJ_G0020654	protein coding gene	Chr13:92098171-92104026 (+)
LP/J	MGP_LPJ_G0020748	protein coding gene	Chr13:97306918-97312804 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020682	protein coding gene	Chr13:104535239-104541125 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021272	protein coding gene	Chr13:95797724-95803579 (+)
PWK/PhJ	MGP_PWKPhJ_G0019860	protein coding gene	Chr13:92096953-92102843 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019684	protein coding gene	Chr13:92085856-92091749 (+)
WSB/EiJ	MGP_WSBEiJ_G0020165	protein coding gene	Chr13:96297342-96303197 (+)

Human Ortholog

F2RL2, coagulation factor II thrombin receptor like 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

F2RL2, coagulation factor II thrombin receptor like 2
Synonyms

PAR-3, PAR3
Links

HGNC:3539

NCBI Gene ID: 2151

neXtProt AC: NX_O00254

UniProt: O00254
Chr Location

5q13.3; chr5:76615482-76623413 (-) GRCh38

MGI Vertebrate Homology

F2rl2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: F2RL2
Gene Tree

F2rl2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available

Homozygous mutation of this gene results in prolonged bleeding times, delayed and reduced thrombin responses in platelets, and protection against thrombosis.

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All GO Annotations

17
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

873
Tissues

125
cDNA Data

12
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase f2rl2

ZFIN f2rl2

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS26702.1

Ensembl

ENSMUSG00000021675 (Evidence)
NCBI Gene

14064

			Length	Strain/Species	Flank
genomic	14064	NCBI Gene Model \| MGI Sequence Detail	5849	C57BL/6J	± kb
transcript	NM_010170	RefSeq \| MGI Sequence Detail	2464	Not Specified
polypeptide	O08675	UniProt \| EBI \| MGI Sequence Detail	369	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001663 proteinase-activated receptor 3

(term hierarchy)
PDB

2PUX
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR003912 Protease-activated receptor

IPR003943 Protease-activated receptor 3
GlyGen

O08675 2 sites, 1 N-linked glycan (1 site)

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All nucleic 19

Genomic 3

cDNA 13

Primer pair 3

Microarray probesets 4

Summaries

All 61

Developmental Gene Expression 9

Gene Ontology 7

Phenotypes 21
Earliest

J:49190 Ishihara H, et al., Protease-activated receptor 3 is a second thrombin receptor in humans. Nature. 1997 Apr 3;386(6624):502-6
Latest

J:350758 Mwirigi J, et al., A Role for Protease Activated Receptor Type 3 (PAR3) in Nociception Demonstrated Through Development of a Novel Peptide Agonist. J Pain. 2021 Jun;22(6):692-706

TSS for F2rl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120720	Chr13:95833359-95833377 (+)	-60 bp
Tssr120721	Chr13:95833403-95833429 (+)	-12 bp
Tssr120722	Chr13:95833440-95833487 (+)	36 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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