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Fhl1 Gene Detail
Summary
  • Symbol
    Fhl1
  • Name
    four and a half LIM domains 1
  • Synonyms
    KyoT, KyoT1, KyoT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298387
    NCBI Gene: 14199
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:55777147-55838706 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 30.06 cM, cytoband A6-A7.1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1179 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298387
 protein coding gene ChrX:55776569-55838706 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035740
 protein coding gene ChrX:52034672-52097440 (+)
A/J MGP_AJ_G0035723
 protein coding gene ChrX:52219636-52285156 (+)
AKR/J MGP_AKRJ_G0035643
 protein coding gene ChrX:53615694-53680805 (+)
BALB/cJ MGP_BALBcJ_G0035710
 protein coding gene ChrX:51692904-51757410 (+)
C3H/HeJ MGP_C3HHeJ_G0035412
 protein coding gene ChrX:52569757-52635960 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036239
 protein coding gene ChrX:53419399-53481842 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033090
 protein coding gene ChrX:51663366-51723795 (+)
CAST/EiJ MGP_CASTEiJ_G0034705
 protein coding gene ChrX:38458431-38548282 (+)
CBA/J MGP_CBAJ_G0035387
 protein coding gene ChrX:54974532-55036252 (+)
DBA/2J MGP_DBA2J_G0035541
 protein coding gene ChrX:51822097-51883644 (+)
FVB/NJ MGP_FVBNJ_G0035491
 protein coding gene ChrX:51419134-51481126 (+)
LP/J MGP_LPJ_G0035629
 protein coding gene ChrX:52621141-52685045 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035527
 protein coding gene ChrX:56515334-56586438 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036255
 protein coding gene ChrX:52064459-52125794 (+)
PWK/PhJ MGP_PWKPhJ_G0034401
 protein coding gene ChrX:36730684-36794473 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034245
 protein coding gene ChrX:39184413-39251463 (+)
WSB/EiJ MGP_WSBEiJ_G0034848
 protein coding gene ChrX:51598589-51660712 (+)



Homology
more
  • Human Ortholog
    FHL1, four and a half LIM domains 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FHL1, four and a half LIM domains 1
  • Synonyms
    FCMSU, FHL-1, FHL1A, FHL1B, FLH1A, KYOT, RBMX1A, RBMX1B, SLIM, SLIM-1, SLIM1, SLIMMER, XMPMA
  • Links
    NCBI Gene ID: 2273
    neXtProt AC: NX_Q13642
    UniProt: Q13642

  • Chr Location
    Xq26.3; chrX:136146702-136211359 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fhl1 mouse models; 4 with human FHL1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit resistance to cardiomyopathy induced by transverse aortic constriction or transgene expression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1053
  • Tissues
    204
  • cDNA Data
    148
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023092 Ensembl Gene Model | MGI Sequence Detail 61560 C57BL/6J ±  kb
    transcript ENSMUST00000114769 Ensembl | MGI Sequence Detail 2770 Not Applicable  
    polypeptide ENSMUSP00000110417 Ensembl | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 158
      cDNA 150
      Primer pair 6
      Other 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 6
      Phenotypes 23
    • Earliest
      J:49742 Kuroiwa A, et al., Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes. Cytogenet Cell Genet. 1998;81(3-4):208-12
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory