Tspyl1 MGI Mouse Gene Detail - MGI:1298395 - testis-specific protein, Y-encoded-like 1

Symbol

Tspyl1
Name

testis-specific protein, Y-encoded-like 1

Feature Type

protein coding gene
IDs

MGI:1298395
NCBI Gene: 22110
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:34158186-34160881 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 18.85 cM
Mapping Data

2 experiments

SNPs within 2kb

161 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1298395	protein coding gene	Chr10:34158186-34161271 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017138	protein coding gene	Chr10:32622331-32625416 (+)
A/J	MGP_AJ_G0017115	protein coding gene	Chr10:31779104-31782179 (+)
AKR/J	MGP_AKRJ_G0017075	protein coding gene	Chr10:32154233-32157321 (+)
BALB/cJ	MGP_BALBcJ_G0017078	protein coding gene	Chr10:31716877-31719952 (+)
C3H/HeJ	MGP_C3HHeJ_G0016898	protein coding gene	Chr10:32449333-32452407 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017536	protein coding gene	Chr10:33553598-33556677 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015233	protein coding gene	Chr10:30100526-30103604 (+)
CAST/EiJ	MGP_CASTEiJ_G0016477	protein coding gene	Chr10:32575277-32578352 (+)
CBA/J	MGP_CBAJ_G0016872	protein coding gene	Chr10:35185453-35188529 (+)
DBA/2J	MGP_DBA2J_G0016977	protein coding gene	Chr10:31350385-31353463 (+)
FVB/NJ	MGP_FVBNJ_G0016972	protein coding gene	Chr10:30853731-30856809 (+)
LP/J	MGP_LPJ_G0017054	protein coding gene	Chr10:32617904-32620989 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017002	protein coding gene	Chr10:35660248-35663325 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017572	protein coding gene	Chr10:32096482-32099567 (+)
PWK/PhJ	MGP_PWKPhJ_G0016258	protein coding gene	Chr10:31126578-31129739 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016042	protein coding gene	Chr10:31972842-31976329 (+)
WSB/EiJ	MGP_WSBEiJ_G0016540	protein coding gene	Chr10:32308544-32311626 (+)

Human Ortholog

TSPYL1, TSPY like 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSPYL1, TSPY like 1
Synonyms

TSPYL
Links

HGNC:12382

NCBI Gene ID: 7259

neXtProt AC: NX_Q9H0U9

UniProt: Q9H0U9
Chr Location

6q22.1; chr6:116267760-116279930 (-) GRCh38

Human Ortholog

TSPYL6, TSPY like 6
Links

HGNC:14521

NCBI Gene ID: 388951

neXtProt AC: NX_Q8N831

UniProt: Q8N831
Chr Location

2p16.2; chr2:54253178-54256229 (-) GRCh38

MGI Vertebrate Homology

Tspyl1 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TSPYL1, TSPYL6
Gene Tree

Tspyl1

Diseases

2 with human TSPYL1 associations

				Human Disease	Mouse Models
				gonadal dysgenesis IDs gonadal dysgenesis DOID:14447 ICD9CM:758.6 MESH:D006059 NCI:C61420 UMLS_CUI:C0018051
				sudden infant death syndrome IDs sudden infant death syndrome DOID:9007 ICD9CM:798.0 MESH:D013398 NCI:C85173 OMIM:272120 UMLS_CUI:C0038644

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Genomic Mutations

2 involving Tspyl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

15
cDNA Data

84
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

2
UniProt

1
CCDS

CCDS23777.1

Ensembl

ENSMUSG00000047514 (Evidence)
NCBI Gene

22110

			Length	Strain/Species	Flank
genomic	22110	NCBI Gene Model \| MGI Sequence Detail	2696	C57BL/6J	± kb
transcript	NM_009433	RefSeq \| MGI Sequence Detail	2696	C57BL/6
polypeptide	O88852	UniProt \| EBI \| MGI Sequence Detail	379	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031622 testis-specific Y-encoded protein 8

(term hierarchy)
InterPro Domains

IPR037231 NAP-like superfamily

IPR002164 Nucleosome assembly protein (NAP)

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All nucleic 85

cDNA 84

Primer pair 1

Microarray probesets 5

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 11
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tspyl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92923	Chr10:34158175-34158189 (+)	-4 bp
Tssr92924	Chr10:34158195-34158274 (+)	49 bp
Tssr92925	Chr10:34159491-34159506 (+)	1,313 bp
Tssr92926	Chr10:34159617-34159640 (+)	1,443 bp
Tssr92927	Chr10:34159869-34159873 (+)	1,685 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24