Map1a MGI Mouse Gene Detail - MGI:1306776 - microtubule-associated protein 1 A

Symbol

Map1a
Name

microtubule-associated protein 1 A
Synonyms

6330416M19Rik, Mtap-1, Mtap1, Mtap1a

Feature Type

protein coding gene
IDs

MGI:1306776
NCBI Gene: 17754
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr2:121120081-121141313 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 60.37 cM
Mapping Data

16 experiments

SNPs within 2kb

351 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1306776	protein coding gene	Chr2:121119608-121141313 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026386	protein coding gene	Chr2:124175583-124196882 (+)
A/J	MGP_AJ_G0026347	protein coding gene	Chr2:119103012-119124331 (+)
AKR/J	MGP_AKRJ_G0026326	protein coding gene	Chr2:122445569-122468625 (+)
BALB/cJ	MGP_BALBcJ_G0026360	protein coding gene	Chr2:119335394-119356952 (+)
C3H/HeJ	MGP_C3HHeJ_G0026106	protein coding gene	Chr2:122925654-122947533 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026807	protein coding gene	Chr2:128246377-128267608 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024187	protein coding gene	Chr2:114145712-114167000 (+)
CAST/EiJ	MGP_CASTEiJ_G0025568	protein coding gene	Chr2:123248767-123272040 (+)
CBA/J	MGP_CBAJ_G0026082	protein coding gene	Chr2:132715484-132736724 (+)
DBA/2J	MGP_DBA2J_G0026221	protein coding gene	Chr2:118497899-118519104 (+)
FVB/NJ	MGP_FVBNJ_G0026183	protein coding gene	Chr2:117317590-117340363 (+)
LP/J	MGP_LPJ_G0026322	protein coding gene	Chr2:124434424-124456011 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026202	protein coding gene	Chr2:136997113-137018331 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026862	protein coding gene	Chr2:122560340-122581580 (+)
PWK/PhJ	MGP_PWKPhJ_G0025304	protein coding gene	Chr2:118108858-118130434 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025103	protein coding gene	Chr2:121771876-121793300 (+)
WSB/EiJ	MGP_WSBEiJ_G0025637	protein coding gene	Chr2:123388314-123409597 (+)

Human Ortholog

MAP1A, microtubule associated protein 1A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP1A, microtubule associated protein 1A
Synonyms

MAP1L, MTAP1A
Links

HGNC:6835

NCBI Gene ID: 4130

neXtProt AC: NX_P78559

UniProt: P78559
Chr Location

15q15.3; chr15:43510954-43531620 (+) GRCh38

MGI Vertebrate Homology

Map1a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MAP1A
Gene Tree

Map1a

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
4 phenotypes from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

14
QTL

2
Radiation induced

1
Spontaneous

1
Targeted

4
Transgenic

1
Genomic Mutations

2 involving Map1a
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

109 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit Purkinje cell degeneration. Mice homozygous for a spontaneous mutation exhibit mild ataxia and Purkinje cell degeneration.

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All GO Annotations

60
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

4
cDNA Data

9
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase map1a

ZFIN map1aa

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All Sequences

50
RefSeq

6
UniProt

2
CCDS

CCDS38215.1, CCDS50685.1

Ensembl

ENSMUSG00000027254 (Evidence)
NCBI Gene

17754

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027254	Ensembl Gene Model \| MGI Sequence Detail	21233	C57BL/6J	± kb
transcript	ENSMUST00000094639	Ensembl \| MGI Sequence Detail	11825	Not Applicable
polypeptide	ENSMUSP00000092223	Ensembl \| MGI Sequence Detail	3014	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010116 microtubule-associated protein 1A

(term hierarchy)
PDB

5GNV
InterPro Domains

IPR026074 Microtubule associated protein 1

IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
GlyGen

Q9QYR6 6 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (5 sites)

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All nucleic 12

cDNA 11

Other 1

Microarray probesets 5

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MGD-MRK-12579, MGD-MRK-12584, MGI:1346024, MGI:1921253, MGI:2139097, MGI:97174

Summaries

All 70

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 17
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:298726 Argent L, et al., Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology. J Biol Chem. 2020 Sep 4;295(36):12716-12726

TSS for Map1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19737	Chr2:121120070-121120087 (+)	-2 bp
Tssr19738	Chr2:121120180-121120191 (+)	105 bp
Tssr19739	Chr2:121120203-121120217 (+)	129 bp
Tssr19740	Chr2:121125918-121125967 (+)	5,862 bp
Tssr19741	Chr2:121129073-121129089 (+)	9,000 bp
Tssr19742	Chr2:121129964-121129982 (+)	9,892 bp
Tssr19743	Chr2:121130844-121130855 (+)	10,769 bp
Tssr19744	Chr2:121131114-121131123 (+)	11,038 bp
Tssr19745	Chr2:121131423-121131437 (+)	11,349 bp
Tssr19746	Chr2:121133875-121133887 (+)	13,800 bp
Tssr19747	Chr2:121133890-121133902 (+)	13,815 bp
Tssr19748	Chr2:121134206-121134224 (+)	14,134 bp
Tssr19749	Chr2:121136466-121136472 (+)	16,388 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24