Egr3 MGI Mouse Gene Detail - MGI:1306780

Symbol

Egr3
Name

early growth response 3
Synonyms

Pilot

Feature Type

protein coding gene
IDs

MGI:1306780
NCBI Gene: 13655
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr14:70314766-70320062 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 36.20 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

84 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1306780	protein coding gene	Chr14:70314652-70320063 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021528	protein coding gene	Chr14:64697561-64700272 (+)
A/J	MGP_AJ_G0021487	protein coding gene	Chr14:63340823-63343535 (+)
AKR/J	MGP_AKRJ_G0021463	protein coding gene	Chr14:65240573-65243285 (+)
BALB/cJ	MGP_BALBcJ_G0021493	protein coding gene	Chr14:63100633-63103345 (+)
C3H/HeJ	MGP_C3HHeJ_G0021270	protein coding gene	Chr14:64951660-64954372 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021932	protein coding gene	Chr14:67613921-67616633 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019472	protein coding gene	Chr14:61176569-61179281 (+)
CAST/EiJ	MGP_CASTEiJ_G0020787	protein coding gene	Chr14:61534557-61537268 (+)
CBA/J	MGP_CBAJ_G0021237	protein coding gene	Chr14:69726596-69729308 (+)
DBA/2J	MGP_DBA2J_G0021360	protein coding gene	Chr14:62721975-62724687 (+)
FVB/NJ	MGP_FVBNJ_G0021339	protein coding gene	Chr14:62149895-62152607 (+)
LP/J	MGP_LPJ_G0021431	protein coding gene	Chr14:65952247-65954958 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021368	protein coding gene	Chr14:68644416-68647128 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021956	protein coding gene	Chr14:64500742-64503454 (+)
PWK/PhJ	MGP_PWKPhJ_G0020531	protein coding gene	Chr14:59483115-59485881 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020364	protein coding gene	Chr14:60426325-60429036 (+)
WSB/EiJ	MGP_WSBEiJ_G0020840	protein coding gene	Chr14:64806462-64809174 (+)

Human Ortholog

EGR3, early growth response 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EGR3, early growth response 3
Synonyms

EGR-3, PILOT
Links

HGNC:3240

NCBI Gene ID: 1960

neXtProt AC: NX_Q06889

UniProt: Q06889
Chr Location

8p21.3; chr8:22687659-22693480 (-) GRCh38

MGI Vertebrate Homology

Egr3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EGR3
Gene Tree

Egr3

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Phenotype Summary

22 phenotypes from 3 alleles in 4 genetic backgrounds
11 phenotypes from multigenic genotypes
57 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

6
Genomic Mutations

1 involving Egr3
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants exhibit partial postnatal lethality, sensory ataxia, resting tremors, blepharoptosis, scoliosis, muscle spindle agenesis, loss of myelinated proprioceptive neurons, and a defect in the strength of sensory-motor connections.

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All GO Annotations

27
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

817
Tissues

59
cDNA Data

10
Literature Summary

23

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase egr3

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All Sequences

48
RefSeq

6
UniProt

4
CCDS

CCDS27246.1, CCDS88701.1

Ensembl

ENSMUSG00000033730 (Evidence)
NCBI Gene

13655

			Length	Strain/Species	Flank
genomic	13655	NCBI Gene Model \| MGI Sequence Detail	5297	C57BL/6J	± kb
transcript	NM_001289925	RefSeq \| MGI Sequence Detail	4053	C57BL/6
polypeptide	P43300	UniProt \| EBI \| MGI Sequence Detail	387	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006939 early growth response protein 3

(term hierarchy)
InterPro Domains

IPR021849 Early growth response, N-terminal

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

P43300 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 15

Genomic 1

cDNA 12

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 112

Developmental Gene Expression 23

Gene Ontology 11

Phenotypes 57
Earliest

J:49519 Patwardhan S, et al., EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors. Oncogene. 1991 Jun;6(6):917-28
Latest

J:354782 Gao Y, et al., Transcription factor EGR2 controls homing and pathogenicity of T(H)17 cells in the central nervous system. Nat Immunol. 2023 Aug;24(8):1331-1344

TSS for Egr3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126387	Chr14:70314356-70314372 (+)	-402 bp
Tssr126388	Chr14:70314375-70314384 (+)	-386 bp
Tssr126389	Chr14:70314617-70314639 (+)	-138 bp
Tssr126390	Chr14:70314655-70314671 (+)	-103 bp
Tssr126391	Chr14:70314755-70314815 (+)	19 bp
Tssr126392	Chr14:70314824-70314833 (+)	63 bp
Tssr126393	Chr14:70315458-70315494 (+)	710 bp
Tssr126394	Chr14:70316690-70316713 (+)	1,936 bp
Tssr126395	Chr14:70316844-70316856 (+)	2,084 bp
Tssr126396	Chr14:70317597-70317612 (+)	2,839 bp
Tssr126397	Chr14:70318604-70318611 (+)	3,842 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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