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Cited2 Gene Detail
Summary
  • Symbol
    Cited2
  • Name
    Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
  • Synonyms
    Mrg1, Msg2, p35srj
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306784
    NCBI Gene: 17684
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:17598966-17601422 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 7.18 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306784
 protein coding gene Chr10:17598452-17601422 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017031
 protein coding gene Chr10:15366857-15369302 (+)
A/J MGP_AJ_G0017009
 protein coding gene Chr10:14756406-14758851 (+)
AKR/J MGP_AKRJ_G0016973
 protein coding gene Chr10:14987500-14989945 (+)
BALB/cJ MGP_BALBcJ_G0016967
 protein coding gene Chr10:14836094-14838539 (+)
C3H/HeJ MGP_C3HHeJ_G0016792
 protein coding gene Chr10:15326070-15328515 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017429
 protein coding gene Chr10:15754083-15756528 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015134
 protein coding gene Chr10:13700916-13703366 (+)
CAST/EiJ MGP_CASTEiJ_G0016374
 protein coding gene Chr10:15129404-15131849 (+)
CBA/J MGP_CBAJ_G0016764
 protein coding gene Chr10:16441016-16443461 (+)
DBA/2J MGP_DBA2J_G0016872
 protein coding gene Chr10:14664800-14667245 (+)
FVB/NJ MGP_FVBNJ_G0016867
 protein coding gene Chr10:14443442-14445888 (+)
LP/J MGP_LPJ_G0016947
 protein coding gene Chr10:15168483-15170928 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016897
 protein coding gene Chr10:16791607-16794052 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017467
 protein coding gene Chr10:14985320-14987765 (+)
PWK/PhJ MGP_PWKPhJ_G0016159
 protein coding gene Chr10:14491594-14494043 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015942
 protein coding gene Chr10:15133126-15135578 (+)
WSB/EiJ MGP_WSBEiJ_G0016436
 protein coding gene Chr10:15054467-15056912 (+)



Homology
more
  • Human Ortholog
    CITED2, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CITED2, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
  • Synonyms
    ASD8, MRG-1, MRG1, P35SRJ, VSD2
  • Links
    NCBI Gene ID: 10370
    neXtProt AC: NX_Q99967
    UniProt: Q99967

  • Chr Location
    6q24.1; chr6:139371807-139374648 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cited2 mouse models; 2 with human CITED2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    90 phenotypes from 12 alleles in 15 genetic backgrounds
    2 phenotypes from multigenic genotypes
    6 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this locus cause cardiac malformations, lethality between E13.5-18.5, neural tube defects, exencephaly, hydrops fetalis, small size, abnormal embryo turning, situs inversus, small spleen, dorsal root and cranial ganglia abnormalities, impaired kidney development and iris coloboma.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    147
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1101
  • Tissues
    312
  • cDNA Data
    127
  • Literature Summary
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039910 Ensembl Gene Model | MGI Sequence Detail 2457 C57BL/6J ±  kb
    transcript ENSMUST00000038107 Ensembl | MGI Sequence Detail 1979 Not Applicable  
    polypeptide ENSMUSP00000038405 Ensembl | MGI Sequence Detail 269 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 137
      cDNA 128
      Primer pair 3
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143671
    References
    more
    • Summaries
      All 126
      Developmental Gene Expression 51
      Diseases 1
      Gene Ontology 26
      Phenotypes 49
    • Earliest
      J:48778 Shioda T, et al., MSG1 and its related protein MRG1 share a transcription activating domain. Gene. 1997 Dec 19;204(1-2):235-41
    • Latest
      J:337939 Kuna M, et al., CITED2 is a conserved regulator of the uterine-placental interface. Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2213622120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory