Aoc3 MGI Mouse Gene Detail - MGI:1306797 - amine oxidase, copper containing 3

Symbol

Aoc3
Name

amine oxidase, copper containing 3
Synonyms

semicarbazide-sensitive amine oxidase, SSAO, VAP1

Feature Type

protein coding gene
IDs

MGI:1306797
NCBI Gene: 11754
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:101221432-101230256 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 64.72 cM, cytoband B2-B5
Mapping Data

2 experiments

SNPs within 2kb

303 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1306797	protein coding gene	Chr11:101221431-101232764 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019196	protein coding gene	Chr11:104175389-104186604 (+)
A/J	MGP_AJ_G0019164	protein coding gene	Chr11:99798249-99811705 (+)
AKR/J	MGP_AKRJ_G0019133	protein coding gene	Chr11:102899730-102912634 (+)
BALB/cJ	MGP_BALBcJ_G0019138	protein coding gene	Chr11:100285241-100297657 (+)
C3H/HeJ	MGP_C3HHeJ_G0018947	protein coding gene	Chr11:103076074-103088348 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019587	protein coding gene	Chr11:107431337-107450227 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017213	protein coding gene	Chr11:97211422-97222791 (+)
CAST/EiJ	MGP_CASTEiJ_G0018501	protein coding gene	Chr11:104065710-104076933 (+)
CBA/J	MGP_CBAJ_G0018916	protein coding gene	Chr11:111865700-111885288 (+)
DBA/2J	MGP_DBA2J_G0019028	protein coding gene	Chr11:99326713-99339574 (+)
FVB/NJ	MGP_FVBNJ_G0019018	protein coding gene	Chr11:98875062-98885975 (+)
LP/J	MGP_LPJ_G0019097	protein coding gene	Chr11:104723619-104734681 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019049	protein coding gene	Chr11:111428986-111440254 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019625	protein coding gene	Chr11:103227673-103238935 (+)
PWK/PhJ	MGP_PWKPhJ_G0018264	protein coding gene	Chr11:100382831-100394377 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018056	protein coding gene	Chr11:102963422-102974541 (+)
WSB/EiJ	MGP_WSBEiJ_G0018550	protein coding gene	Chr11:103225380-103239456 (+)

Human Ortholog

AOC3, amine oxidase copper containing 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AOC3, amine oxidase copper containing 3
Synonyms

HPAO, SSAO, VAP-1, VAP1
Links

HGNC:550

NCBI Gene ID: 8639

neXtProt AC: NX_Q16853

UniProt: Q16853
Chr Location

17q21.31; chr17:42851184-42858130 (+) GRCh38

MGI Vertebrate Homology

Aoc3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AOC3
Gene Tree

Aoc3

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

1
Gene trapped

9
Targeted

4
Genomic Mutations

1 involving Aoc3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available

Homozygous null mice display decreased lymphocyte migration and homing in response to inflammation.

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All GO Annotations

48
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

916
Tissues

165
cDNA Data

18
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase aoc3

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All Sequences

37
RefSeq

6
UniProt

2
CCDS

CCDS25465.1

Ensembl

ENSMUSG00000019326 (Evidence)
NCBI Gene

11754

			Length	Strain/Species	Flank
genomic	11754	NCBI Gene Model \| MGI Sequence Detail	8825	C57BL/6J	± kb
transcript	NM_009675	RefSeq \| MGI Sequence Detail	4396	C57BL/6
polypeptide	O70423	UniProt \| EBI \| MGI Sequence Detail	765	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004087 membrane primary amine oxidase

(term hierarchy)
EC

1.4.3.-, 1.4.3.21
InterPro Domains

IPR000269 Copper amine oxidase

IPR015798 Copper amine oxidase, catalytic domain

IPR036460 Copper amine oxidase, catalytic domain superfamily

IPR049947 Copper amine oxidase, copper-binding site

IPR015800 Copper amine oxidase, N2-terminal

IPR015802 Copper amine oxidase, N3-terminal

IPR016182 Copper amine oxidase, N-terminal

IPR049948 Copper amine oxidase, TPQ-binding site
GlyGen

O70423 7 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 25

Genomic 6

cDNA 18

Primer pair 1

Microarray probesets 3

Summaries

All 76

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 29
Earliest

J:47790 Bono P, et al., Cloning and characterization of mouse vascular adhesion protein-1 reveals a novel molecule with enzymatic activity. J Immunol. 1998 Jun 1;160(11):5563-71
Latest

J:309136 Jargaud V, et al., Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity. J Physiol Biochem. 2021 Feb;77(1):141-154

TSS for Aoc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105085	Chr11:101221599-101221621 (+)	178 bp
Tssr105086	Chr11:101221636-101221646 (+)	209 bp
Tssr105087	Chr11:101221658-101221684 (+)	239 bp
Tssr105088	Chr11:101221689-101221700 (+)	263 bp
Tssr105089	Chr11:101221705-101221712 (+)	277 bp
Tssr105090	Chr11:101228467-101228471 (+)	7,037 bp
Tssr105091	Chr11:101228588-101228603 (+)	7,164 bp
Tssr105092	Chr11:101229063-101229092 (+)	7,646 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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