Vwa7 MGI Mouse Gene Detail - MGI:1306798 - von Willebrand factor A domain containing 7

Symbol

Vwa7
Name

von Willebrand factor A domain containing 7
Synonyms

D17H6S56E-3, G7c

Feature Type

protein coding gene
IDs

MGI:1306798
NCBI Gene: 27762
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:35235555-35245717 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.55 cM
Mapping Data

3 experiments

Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1306798	protein coding gene	Chr17:35235388-35245717 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023606	protein coding gene	Chr17:35149060-35159475 (+)
A/J	MGP_AJ_G0023566	protein coding gene	Chr17:33990823-34000991 (+)
AKR/J	MGP_AKRJ_G0023534	protein coding gene	Chr17:34460138-34470296 (+)
BALB/cJ	MGP_BALBcJ_G0023572	protein coding gene	Chr17:34120871-34131022 (+)
C3H/HeJ	MGP_C3HHeJ_G0023333	protein coding gene	Chr17:34855544-34865711 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024011	protein coding gene	Chr17:36490325-36502090 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021492	protein coding gene	Chr17:31757161-31767340 (+)
CAST/EiJ	MGP_CASTEiJ_G0022830	protein coding gene	Chr17:34858919-34869095 (+)
CBA/J	MGP_CBAJ_G0023311	protein coding gene	Chr17:38001019-38011314 (+)
DBA/2J	MGP_DBA2J_G0023439	protein coding gene	Chr17:33308982-33319497 (+)
FVB/NJ	MGP_FVBNJ_G0023406	protein coding gene	Chr17:33145266-33155671 (+)
LP/J	MGP_LPJ_G0023516	protein coding gene	Chr17:35476911-35488265 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023428	protein coding gene	Chr17:36931322-36941473 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024056	protein coding gene	Chr17:34684354-34694514 (+)
PWK/PhJ	MGP_PWKPhJ_G0022577	protein coding gene	Chr17:32140519-32150844 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022397	protein coding gene	Chr17:32694116-32704300 (+)
WSB/EiJ	MGP_WSBEiJ_G0022893	protein coding gene	Chr17:34797314-34807465 (+)

Human Ortholog

VWA7, von Willebrand factor A domain containing 7

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VWA7, von Willebrand factor A domain containing 7
Synonyms

C6orf27, G7c, NG37
Links

HGNC:13939

NCBI Gene ID: 80737

neXtProt AC: NX_Q9Y334

UniProt: Q9Y334
Chr Location

6p21.33; chr6:31765590-31777328 (-) GRCh38

MGI Vertebrate Homology

Vwa7 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: VWA7
Gene Tree

Vwa7

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

4
Targeted

3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

47 strains or lines available

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All GO Annotations

1
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN vwa7

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All Sequences

40
RefSeq

6
UniProt

3
CCDS

CCDS28672.1, CCDS84299.1

Ensembl

ENSMUSG00000007030 (Evidence)
NCBI Gene

27762

			Length	Strain/Species	Flank
genomic	ENSMUSG00000007030	Ensembl Gene Model \| MGI Sequence Detail	10163	C57BL/6J	± kb
transcript	ENSMUST00000007245	Ensembl \| MGI Sequence Detail	4313	Not Applicable
polypeptide	ENSMUSP00000007245	Ensembl \| MGI Sequence Detail	891	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030430 von Willebrand factor A domain-containing protein 7

(term hierarchy)
InterPro Domains

IPR052577 von Willebrand factor A domain-containing protein 7

IPR036465 von Willebrand factor A-like domain superfamily
GlyGen

Q9JHA8 3 sites, 2 N-linked glycans (2 sites)

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All nucleic 5

Genomic 3

cDNA 2

Microarray probesets 2

Summaries

All 25

Gene Ontology 1

Phenotypes 7
Earliest

J:44921 Snoek M, et al., Molecular analysis of the major MHC recombinational hot spot located within the G7c gene of the murine class III region that is involved in disease susceptibility. J Immunol. 1998 Jan 1;160(1):266-72
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Vwa7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144170	Chr17:35235494-35235522 (+)	-47 bp
Tssr144171	Chr17:35235552-35235580 (+)	11 bp
Tssr144172	Chr17:35243083-35243089 (+)	7,531 bp
Tssr144173	Chr17:35243112-35243121 (+)	7,562 bp
Tssr144174	Chr17:35243338-35243352 (+)	7,790 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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