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Tff2 Gene Detail
Summary
  • Symbol
    Tff2
  • Name
    trefoil factor 2 (spasmolytic protein 1)
  • Synonyms
    mSP, SP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306805
    NCBI Gene: 21785
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
  • Candidate for QTL
    5 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:31360036-31363256 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.80 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    319 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306805
 protein coding gene Chr17:31360023-31363256 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023482
 protein coding gene Chr17:30881090-30884206 (-)
A/J MGP_AJ_G0023440
 protein coding gene Chr17:29871153-29874465 (-)
AKR/J MGP_AKRJ_G0023405
 protein coding gene Chr17:30116483-30119600 (-)
BALB/cJ MGP_BALBcJ_G0023445
 protein coding gene Chr17:29979097-29982301 (-)
C3H/HeJ MGP_C3HHeJ_G0023206
 protein coding gene Chr17:30502035-30505236 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023887
 protein coding gene Chr17:31948558-31951787 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021361
 protein coding gene Chr17:27012702-27015690 (-)
CAST/EiJ MGP_CASTEiJ_G0022707
 protein coding gene Chr17:30528254-30532628 (-)
CBA/J MGP_CBAJ_G0023181
 protein coding gene Chr17:33372617-33375854 (-)
DBA/2J MGP_DBA2J_G0023311
 protein coding gene Chr17:29288855-29292366 (-)
FVB/NJ MGP_FVBNJ_G0023281
 protein coding gene Chr17:29072651-29075833 (-)
LP/J MGP_LPJ_G0023389
 protein coding gene Chr17:31101058-31104194 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023299
 protein coding gene Chr17:32433754-32437242 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023929
 protein coding gene Chr17:30492125-30495454 (-)
PWK/PhJ MGP_PWKPhJ_G0022457
 protein coding gene Chr17:28104598-28108044 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022275
 protein coding gene Chr17:28477524-28480518 (-)
WSB/EiJ MGP_WSBEiJ_G0022769
 protein coding gene Chr17:30449257-30452319 (-)



Homology
more
  • Human Ortholog
    TFF2, trefoil factor 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TFF2, trefoil factor 2
  • Synonyms
    SML1, SP
  • Links
    NCBI Gene ID: 7032
    neXtProt AC: NX_Q03403
    UniProt: Q03403

  • Chr Location
    21q22.3; chr21:42346357-42350997 (-)  GRCh38
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in decreased gastric proliferation, increased acid secretion, increased susceptibility to gastric ulceration after indomethacin administration, and altered regulation of genes involved in adaptive and immune responses in the pyloric antrum.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    869
  • Tissues
    135
  • cDNA Data
    26
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21785 NCBI Gene Model | MGI Sequence Detail 3221 C57BL/6J ±  kb
    transcript NM_009363 RefSeq | MGI Sequence Detail 571 ZRU/MplStud  
    polypeptide Q03404 UniProt | EBI | MGI Sequence Detail 129 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 26
      Primer pair 4
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 13
      Diseases 3
      Gene Ontology 6
      Phenotypes 45
    • Earliest
      J:49831 Tomasetto C, et al., hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. EMBO J. 1990 Feb;9(2):407-14
    • Latest
      J:353482 Ortiz JA, et al., Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for beta-Cell Function During Aging. Diabetes. 2024 Sep 1;73(9):1447-1461
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory