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Suclg2 Gene Detail
Summary
  • Symbol
    Suclg2
  • Name
    succinate-Coenzyme A ligase, GDP-forming, beta subunit
  • Synonyms
    D6Wsu120e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306824
    NCBI Gene: 20917
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:95449990-95695781 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 44.63 cM, cytoband D3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6606 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306824
 protein coding gene Chr6:95449990-95695799 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031068
 protein coding gene Chr6:97265081-97514293 (-)
A/J MGP_AJ_G0031037
 protein coding gene Chr6:93582248-93826163 (-)
AKR/J MGP_AKRJ_G0030968
 protein coding gene Chr6:96149018-96409818 (-)
BALB/cJ MGP_BALBcJ_G0031048
 protein coding gene Chr6:93538717-93776165 (-)
C3H/HeJ MGP_C3HHeJ_G0030660
 protein coding gene Chr6:88013407-88265130 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031507
 protein coding gene Chr6:99695132-99949879 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028672
 protein coding gene Chr6:91517473-91756303 (-)
CAST/EiJ MGP_CASTEiJ_G0030155
 protein coding gene Chr6:96369838-96615538 (-)
CBA/J MGP_CBAJ_G0030734
 protein coding gene Chr6:103501907-103767684 (-)
DBA/2J MGP_DBA2J_G0030887
 protein coding gene Chr6:92730422-92969075 (-)
FVB/NJ MGP_FVBNJ_G0030841
 protein coding gene Chr6:91934555-92174617 (-)
LP/J MGP_LPJ_G0030967
 protein coding gene Chr6:97266969-97524993 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030875
 protein coding gene Chr6:107454874-107700592 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031534
 protein coding gene Chr6:96018117-96272574 (-)
PWK/PhJ MGP_PWKPhJ_G0029871
 protein coding gene Chr6:91761781-91996926 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029699
 protein coding gene Chr6:94958335-95215611 (-)
WSB/EiJ MGP_WSBEiJ_G0030239
 protein coding gene Chr6:96492022-96742999 (-)



Homology
more
  • Human Ortholog
    SUCLG2, succinate-CoA ligase GDP-forming subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SUCLG2, succinate-CoA ligase GDP-forming subunit beta
  • Synonyms
    GBETA, G-SCS, GTPSCS
  • Links
    NCBI Gene ID: 8801
    neXtProt AC: NX_Q96I99
    UniProt: Q96I99

  • Chr Location
    3p14.1; chr3:67360460-67654612 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout with a gene trap is embryonic lethal. Heterozygosity has a mild effect on mitochondrial respiration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1033
  • Tissues
    134
  • cDNA Data
    15
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061838 Ensembl Gene Model | MGI Sequence Detail 245792 C57BL/6J ±  kb
    transcript ENSMUST00000204224 Ensembl | MGI Sequence Detail 3367 Not Applicable  
    polypeptide ENSMUSP00000144827 Ensembl | MGI Sequence Detail 433 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000015813 succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
      (term hierarchy)
    • EC
      6.2.1.4
    • InterPro Domains
      IPR005811 ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain
      IPR011761 ATP-grasp fold
      IPR013815 ATP-grasp fold, subdomain 1
      IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
      IPR034722 Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
      IPR005809 Succinate--CoA ligase-like, beta subunit
      IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site
      IPR016102 Succinyl-CoA synthetase-like
    • GlyGen
      Q9Z2I8 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 15
      Primer pair 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35775, MGI:107309, MGI:2141376, MGI:2141706
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 12
      Gene Ontology 12
      Phenotypes 18
    • Earliest
      J:50333 Johnson JD, et al., Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. J Biol Chem. 1998 Oct 16;273(42):27580-6
    • Latest
      J:347601 Shen T, et al., Cardiac-specific deletion of heat shock protein 60 induces mitochondrial stress and disrupts heart development in mice. Biochem Biophys Res Commun. 2024 May 28;710:149883
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory