Hspa13 MGI Mouse Gene Detail - MGI:1309463 - heat shock protein 70 family, member 13

Symbol

Hspa13
Name

heat shock protein 70 family, member 13
Synonyms

1600002I10Rik, 60kDa, B230217N24Rik, Stch

Feature Type

protein coding gene
IDs

MGI:1309463
NCBI Gene: 110920
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr16:75552078-75564575 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 43.36 cM, cytoband C3.2
Mapping Data

6 experiments

SNPs within 2kb

521 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1309463	protein coding gene	Chr16:75542319-75564575 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022954	protein coding gene	Chr16:75772476-75784098 (-)
A/J	MGP_AJ_G0022922	protein coding gene	Chr16:72436247-72448078 (-)
AKR/J	MGP_AKRJ_G0022892	protein coding gene	Chr16:74660545-74672176 (-)
BALB/cJ	MGP_BALBcJ_G0022924	protein coding gene	Chr16:72832963-72844594 (-)
C3H/HeJ	MGP_C3HHeJ_G0022686	protein coding gene	Chr16:75098269-75109900 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023372	protein coding gene	Chr16:78219431-78231062 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020875	protein coding gene	Chr16:71000810-71012576 (-)
CAST/EiJ	MGP_CASTEiJ_G0022209	protein coding gene	Chr16:75500029-75511683 (-)
CBA/J	MGP_CBAJ_G0022656	protein coding gene	Chr16:81552971-81564602 (-)
DBA/2J	MGP_DBA2J_G0022789	protein coding gene	Chr16:72276681-72288322 (-)
FVB/NJ	MGP_FVBNJ_G0022764	protein coding gene	Chr16:71668623-71680254 (-)
LP/J	MGP_LPJ_G0022859	protein coding gene	Chr16:75569139-75580761 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022782	protein coding gene	Chr16:84649163-84661685 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023389	protein coding gene	Chr16:74980732-74992375 (-)
PWK/PhJ	MGP_PWKPhJ_G0021951	protein coding gene	Chr16:72533951-72546049 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021781	protein coding gene	Chr16:74615228-74627871 (-)
WSB/EiJ	MGP_WSBEiJ_G0022256	protein coding gene	Chr16:75159489-75171120 (-)

Human Ortholog

HSPA13, heat shock protein family A (Hsp70) member 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSPA13, heat shock protein family A (Hsp70) member 13
Synonyms

STCH
Links

HGNC:11375

NCBI Gene ID: 6782

neXtProt AC: NX_P48723

UniProt: P48723
Chr Location

21q11.2; chr21:14371115-14383484 (-) GRCh38

MGI Vertebrate Homology

Hspa13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HSPA13
Gene Tree

Hspa13

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References

1 with disease annotations

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Phenotype Summary

16 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

1
Targeted

8
Genomic Mutations

5 involving Hspa13
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele in immune cells exhibit reduction in plasmablast, plasma cell, and antibodies induced LPS or sheep red blood cells, and reduced susceptibility to systemic lupus erythematosus.

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

771
Tissues

63
cDNA Data

16
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hspa13

ZFIN hspa13

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All Sequences

53
RefSeq

5
UniProt

2
CCDS

CCDS28273.1

Ensembl

ENSMUSG00000032932 (Evidence)
NCBI Gene

110920

			Length	Strain/Species	Flank
genomic	110920	NCBI Gene Model \| MGI Sequence Detail	12498	C57BL/6J	± kb
transcript	NR_027492	RefSeq \| MGI Sequence Detail	4175	ZRU/MplStud
polypeptide	Q8BM72	UniProt \| EBI \| MGI Sequence Detail	471	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008804 heat shock 70 kDa protein 13

(term hierarchy)
InterPro Domains

IPR043129 ATPase, nucleotide binding domain

IPR042048 Heat shock 70kDa protein 13

IPR018181 Heat shock protein 70, conserved site

IPR013126 Heat shock protein 70 family
GlyGen

Q8BM72 3 sites, 6 N-linked glycans (3 sites)

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All nucleic 19

Genomic 1

cDNA 17

Primer pair 1

Microarray probesets 8

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MGI:1917025, MGI:1926096, MGI:2146589

Summaries

All 52

Developmental Gene Expression 3

Diseases 1

Gene Ontology 5

Phenotypes 18
Earliest

J:47556 Reeves RH, et al., Stch maps to mouse chromosome 16, extending the conserved synteny with human chromosome 21. Genomics. 1998 Apr 1;49(1):156-7
Latest

J:335294 Redhead Y, et al., Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077

TSS for Hspa13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr141800	Chr16:75563961-75563963 (-)	613 bp
Tssr141799	Chr16:75563646-75563685 (-)	909 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24