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Gstm5 Gene Detail
Summary
  • Symbol
    Gstm5
  • Name
    glutathione S-transferase, mu 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309466
    NCBI Gene: 14866
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:107803240-107806002 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.83 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309466
 protein coding gene Chr3:107803137-107806002 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027757
 protein coding gene Chr3:109413242-109416107 (+)
A/J MGP_AJ_G0027717
 protein coding gene Chr3:105950441-105953306 (+)
AKR/J MGP_AKRJ_G0027682
 protein coding gene Chr3:108523925-108526790 (+)
BALB/cJ MGP_BALBcJ_G0027729
 protein coding gene Chr3:105641955-105644820 (+)
C3H/HeJ MGP_C3HHeJ_G0027459
 protein coding gene Chr3:108869071-108871936 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028173
 protein coding gene Chr3:113499440-113502305 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025511
 protein coding gene Chr3:102097384-102100241 (+)
CAST/EiJ MGP_CASTEiJ_G0026915
 protein coding gene Chr3:108249482-108252354 (+)
CBA/J MGP_CBAJ_G0027434
 protein coding gene Chr3:117351521-117354386 (+)
DBA/2J MGP_DBA2J_G0027576
 protein coding gene Chr3:105135457-105138322 (+)
FVB/NJ MGP_FVBNJ_G0027544
 protein coding gene Chr3:103016583-103019448 (+)
LP/J MGP_LPJ_G0027683
 protein coding gene Chr3:110833284-110836149 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027574
 protein coding gene Chr3:123430163-123433028 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028228
 protein coding gene Chr3:108123853-108126717 (+)
PWK/PhJ MGP_PWKPhJ_G0026641
 protein coding gene Chr3:104880161-104883010 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026461
 protein coding gene Chr3:106253275-106256137 (+)
WSB/EiJ MGP_WSBEiJ_G0026995
 protein coding gene Chr3:108643138-108646003 (+)



Homology
more
  • Human Ortholog
    GSTM3, glutathione S-transferase mu 3
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSTM3, glutathione S-transferase mu 3
  • Synonyms
    GST5, GSTB, GSTM3-3, GSTM3TV2, GTM3, hGSTM3-3
  • Links
    NCBI Gene ID: 2947
    neXtProt AC: NX_P21266
    UniProt: P21266

  • Chr Location
    1p13.3; chr1:109733932-109741038 (-)  GRCh38
Human Diseases
more
  • Diseases
    8 with human GSTM3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1013
  • Tissues
    137
  • cDNA Data
    261
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14866 NCBI Gene Model | MGI Sequence Detail 2763 C57BL/6J ±  kb
    transcript NM_010360 RefSeq | MGI Sequence Detail 842 C57BL/6  
    polypeptide P48774 UniProt | EBI | MGI Sequence Detail 224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • EC
      2.5.1.18
    • InterPro Domains
      IPR004046 Glutathione S-transferase, C-terminal
      IPR036282 Glutathione S-transferase, C-terminal domain superfamily
      IPR010987 Glutathione S-transferase, C-terminal-like
      IPR003081 Glutathione S-transferase, Mu class
      IPR004045 Glutathione S-transferase, N-terminal
      IPR050213 Glutathione S-transferase superfamily
      IPR040079 Glutathione transferase family
      IPR036249 Thioredoxin-like superfamily
    • GlyGen
      P48774 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 262
      cDNA 261
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:46014 Pearson WR, et al., Increased synthesis of glutathione S-transferases in response to anticarcinogenic antioxidants. Cloning and measurement of messenger RNA. J Biol Chem. 1983 Feb 10;258(3):2052-62
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory