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Trip12 Gene Detail
Summary
  • Symbol
    Trip12
  • Name
    thyroid hormone receptor interactor 12
  • Synonyms
    1110036I07Rik, 6720416K24Rik, Gtl6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309481
    NCBI Gene: 14897
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:84698910-84818237 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 43.42 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1822 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309481
 protein coding gene Chr1:84698910-84818285 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016228
 protein coding gene Chr1:85757917-85886098 (-)
A/J MGP_AJ_G0016211
 protein coding gene Chr1:82676044-82795335 (-)
AKR/J MGP_AKRJ_G0016168
 protein coding gene Chr1:84937640-85059093 (-)
BALB/cJ MGP_BALBcJ_G0016166
 protein coding gene Chr1:82811646-82937104 (-)
C3H/HeJ MGP_C3HHeJ_G0015996
 protein coding gene Chr1:85318219-85447834 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016619
 protein coding gene Chr1:89028460-89179524 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014339
 protein coding gene Chr1:77772772-77889705 (-)
CAST/EiJ MGP_CASTEiJ_G0015581
 protein coding gene Chr1:84730557-84859564 (-)
CBA/J MGP_CBAJ_G0015970
 protein coding gene Chr1:91892238-92019067 (-)
DBA/2J MGP_DBA2J_G0016071
 protein coding gene Chr1:81969436-82091914 (-)
FVB/NJ MGP_FVBNJ_G0016074
 protein coding gene Chr1:81051188-81173682 (-)
LP/J MGP_LPJ_G0016144
 protein coding gene Chr1:86808431-86937713 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016094
 protein coding gene Chr1:95253201-95398969 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016666
 protein coding gene Chr1:85114665-85245093 (-)
PWK/PhJ MGP_PWKPhJ_G0015367
 protein coding gene Chr1:81370436-81497247 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015145
 protein coding gene Chr1:84296474-84426599 (-)
WSB/EiJ MGP_WSBEiJ_G0015642
 protein coding gene Chr1:84882624-85009104 (-)



Homology
more
  • Human Ortholog
    TRIP12, thyroid hormone receptor interactor 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIP12, thyroid hormone receptor interactor 12
  • Synonyms
    MRD49, TRIP-12, TRIPC, ULF
  • Links
    NCBI Gene ID: 9320
    neXtProt AC: NX_Q14669
    UniProt: Q14669

  • Chr Location
    2q36.3; chr2:229763837-229923239 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TRIP12 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 1 genetic background
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit complete embryonic lethality during organogenesis associated with embryonic growth retardation and abnormal placenta development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    18
  • cDNA Data
    31
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026219 Ensembl Gene Model | MGI Sequence Detail 119328 C57BL/6J ±  kb
transcript ENSMUST00000027421 Ensembl | MGI Sequence Detail 9632 Not Applicable  
polypeptide ENSMUSP00000027421 Ensembl | MGI Sequence Detail 2025 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 31

    Microarray probesets 9
Other
Accession IDs
less
MGI:1921001, MGI:2142937, MGI:2444080
References
more
  • Summaries
    All 49
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 18
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:350485 Brunet M, et al., The E3 ubiquitin ligase TRIP12 is required for pancreatic acinar cell plasticity and pancreatic carcinogenesis. J Pathol. 2024 Aug;263(4-5):466-481
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory