Gsta4 MGI Mouse Gene Detail - MGI:1309515 - glutathione S-transferase, alpha 4

Symbol

Gsta4
Name

glutathione S-transferase, alpha 4
Synonyms

GST 5.7, mGsta4

Feature Type

protein coding gene
IDs

MGI:1309515
NCBI Gene: 14860
Member of

Gsta cluster
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:78099248-78116631 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 43.65 cM, cytoband E1
Mapping Data

4 experiments

SNPs within 2kb

531 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1309515	protein coding gene	Chr9:78090056-78116631 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035059	protein coding gene	Chr9:78662739-78680099 (+)
A/J	MGP_AJ_G0035040	protein coding gene	Chr9:75916883-75934362 (+)
AKR/J	MGP_AKRJ_G0034969	protein coding gene	Chr9:77721057-77738541 (+)
BALB/cJ	MGP_BALBcJ_G0035032	protein coding gene	Chr9:75597210-75614695 (+)
C3H/HeJ	MGP_C3HHeJ_G0034741	protein coding gene	Chr9:78239190-78256674 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035550	protein coding gene	Chr9:80769833-80787193 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032461	protein coding gene	Chr9:75148450-75163495 (+)
CAST/EiJ	MGP_CASTEiJ_G0034063	protein coding gene	Chr9:78585015-78600607 (+)
CBA/J	MGP_CBAJ_G0034713	protein coding gene	Chr9:83538654-83556132 (+)
DBA/2J	MGP_DBA2J_G0034873	protein coding gene	Chr9:75577616-75595091 (+)
FVB/NJ	MGP_FVBNJ_G0034815	protein coding gene	Chr9:74823219-74840674 (+)
LP/J	MGP_LPJ_G0034954	protein coding gene	Chr9:78887952-78905303 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034856	protein coding gene	Chr9:84773785-84791269 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035573	protein coding gene	Chr9:77897300-77914764 (+)
PWK/PhJ	MGP_PWKPhJ_G0033767	protein coding gene	Chr9:75811586-75827680 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033600	protein coding gene	Chr9:78133332-78150656 (+)
WSB/EiJ	MGP_WSBEiJ_G0034175	protein coding gene	Chr9:77826211-77844551 (+)

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MGI Vertebrate Homology

Gsta4 stringent orthology
1 mouse;1 rat;2 zebrafish
Gene Tree

Gsta4

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Phenotype Summary

16 phenotypes from 3 alleles in 3 genetic backgrounds
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

149
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

142
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Gsta4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

65 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display increased sensitivity to oxidative stress, increased alanine and aspartate transaminase levels, increased susceptibility to bacterial infection, reduced litter size, and impaired glucose tolerance.

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All GO Annotations

10
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1545
Tissues

197
cDNA Data

111
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gsta4

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All Sequences

44
RefSeq

2
UniProt

2
CCDS

CCDS23357.1

Ensembl

ENSMUSG00000032348 (Evidence)
NCBI Gene

14860

			Length	Strain/Species	Flank
genomic	14860	NCBI Gene Model \| MGI Sequence Detail	17384	C57BL/6J	± kb
transcript	NM_010357	RefSeq \| MGI Sequence Detail	910	C57BL/6
polypeptide	P24472	UniProt \| EBI \| MGI Sequence Detail	222	Not Applicable

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UniProt

2 Sequences
PDB

1B48, 1GUK
EC

2.5.1.18
InterPro Domains

IPR003080 Glutathione S-transferase, alpha class

IPR004046 Glutathione S-transferase, C-terminal

IPR036282 Glutathione S-transferase, C-terminal domain superfamily

IPR010987 Glutathione S-transferase, C-terminal-like

IPR004045 Glutathione S-transferase, N-terminal

IPR050213 Glutathione S-transferase superfamily

IPR040079 Glutathione transferase family

IPR036249 Thioredoxin-like superfamily
GlyGen

P24472 1 site, 1 O-linked glycan (1 site)

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All nucleic 114

cDNA 111

Primer pair 2

Other 1

Microarray probesets 3

Summaries

All 78

Developmental Gene Expression 12

Gene Ontology 6

Phenotypes 34
Earliest

J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gsta4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86269	Chr9:78099254-78099281 (+)	20 bp
Tssr86270	Chr9:78099288-78099305 (+)	49 bp
Tssr86271	Chr9:78105401-78105423 (+)	6,164 bp
Tssr86272	Chr9:78111555-78111569 (+)	12,314 bp
Tssr86273	Chr9:78111573-78111589 (+)	12,333 bp
Tssr86274	Chr9:78113298-78113311 (+)	14,057 bp
Tssr86275	Chr9:78116558-78116581 (+)	17,322 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24