Alcw3 QTL Detail

Summary

• Symbol
  Alcw3
• Name
  alcohol withdrawal 3
• Synonyms
  Caws4

• Feature Type
  QTL
• IDs
  MGI:1309538
  NCBI Gene: 112088
• Candidate Genes
  2 Genes

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 11, 25.18 cM (cM position of peak correlated region/marker)
• Mapping Data
  3 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 2 alleles in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  112088

References

• Summaries
  All 7

  Phenotypes 1
• Earliest
  J:36168 Crabbe J, Quantitative trait locus gene mapping: a new method for locating alcohol response genes. Addict Biol. 1996;1(3):229-35
• Latest
  J:98588 Hood HM, et al., Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11. Genes Brain Behav. 2006 Feb;5(1):1-10

Candidate Genes for Alcw3:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Gabrg2	Chr11:41801030-41891684 (-)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 11, candidate genes identified for Alcw3 (18 cM) are Hba-a1 (16cM) and Gabrg2 (19 cM).
Hba-a1	Chr11:32233672-32234486 (+)	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 11, candidate genes identified for Alcw3 (18 cM) are Hba-a1 (16cM) and Gabrg2 (19 cM).