Krt32 MGI Mouse Gene Detail - MGI:1309995

Symbol

Krt32
Name

keratin 32
Synonyms

Krt1-2, mHa2

Feature Type

protein coding gene
IDs

MGI:1309995
NCBI Gene: 16670
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:99971674-99979095 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 63.40 cM
Mapping Data

4 experiments

SNPs within 2kb

266 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1309995	protein coding gene	Chr11:99971674-99979100 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019138	protein coding gene	Chr11:102828029-102835385 (-)
A/J	MGP_AJ_G0019106	protein coding gene	Chr11:98487191-98494541 (-)
AKR/J	MGP_AKRJ_G0019075	protein coding gene	Chr11:101531355-101538727 (-)
BALB/cJ	MGP_BALBcJ_G0019080	protein coding gene	Chr11:99003508-99010883 (-)
C3H/HeJ	MGP_C3HHeJ_G0018889	protein coding gene	Chr11:101727176-101734549 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019529	protein coding gene	Chr11:105995814-106003197 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017156	protein coding gene	Chr11:95940450-95947883 (-)
CAST/EiJ	MGP_CASTEiJ_G0018443	protein coding gene	Chr11:102707759-102715120 (-)
CBA/J	MGP_CBAJ_G0018858	protein coding gene	Chr11:110430979-110438327 (-)
DBA/2J	MGP_DBA2J_G0018971	protein coding gene	Chr11:98061611-98068983 (-)
FVB/NJ	MGP_FVBNJ_G0018960	protein coding gene	Chr11:97561908-97569115 (-)
LP/J	MGP_LPJ_G0019039	protein coding gene	Chr11:103367107-103374465 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018991	protein coding gene	Chr11:110054611-110061983 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019567	protein coding gene	Chr11:101908320-101915792 (-)
PWK/PhJ	MGP_PWKPhJ_G0018206	protein coding gene	Chr11:99092483-99099912 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017998	protein coding gene	Chr11:101603961-101613433 (-)
WSB/EiJ	MGP_WSBEiJ_G0018492	protein coding gene	Chr11:101876072-101883439 (-)

Human Ortholog

KRT32, keratin 32

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KRT32, keratin 32
Synonyms

HA2, hHa2, HKA2, KRTHA2
Links

HGNC:6449

NCBI Gene ID: 3882

neXtProt AC: NX_Q14532

UniProt: Q14532
Chr Location

17q21.2; chr17:41459513-41467386 (-) GRCh38

MGI Vertebrate Homology

Krt32 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KRT32
Gene Tree

Krt32

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

5
Targeted

3
Genomic Mutations

2 involving Krt32
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

11
cDNA Data

8
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

30
RefSeq

2
UniProt

2
CCDS

CCDS25406.1, CCDS56805.1

Ensembl

ENSMUSG00000046095 (Evidence)
NCBI Gene

16670

			Length	Strain/Species	Flank
genomic	16670	NCBI Gene Model \| MGI Sequence Detail	7422	C57BL/6J	± kb
transcript	NM_001159374	RefSeq \| MGI Sequence Detail	1716	ZRU/MplStud
polypeptide	Q62168	UniProt \| EBI \| MGI Sequence Detail	407	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009470 keratin, type I cuticular Ha2

(term hierarchy)
InterPro Domains

IPR018039 Intermediate filament protein, conserved site

IPR039008 Intermediate filament, rod domain

IPR002957 Keratin, type I

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All nucleic 13

Genomic 2

cDNA 10

Primer pair 1

Microarray probesets 1

Summaries

All 42

Developmental Gene Expression 6

Gene Ontology 3

Phenotypes 13
Earliest

J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
Latest

J:354137 Shi P, et al., Loss-of-function mutations in Keratin 32 gene disrupt skin immune homeostasis in pityriasis rubra pilaris. Nat Commun. 2024 Jul 24;15(1):6259

TSS for Krt32:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110728	Chr11:99979091-99979096 (-)	1 bp
Tssr110727	Chr11:99976269-99976274 (-)	2,823 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24