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Clip2 Gene Detail
Summary
  • Symbol
    Clip2
  • Name
    CAP-GLY domain containing linker protein 2
  • Synonyms
    CLIP-115, Cyln2, WSCR4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313136
    NCBI Gene: 269713
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:134518237-134581288 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 74.63 cM, cytoband G
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2233 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1313136
 protein coding gene Chr5:134518237-134582922 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030157
 protein coding gene Chr5:138900861-138964521 (-)
A/J MGP_AJ_G0030125
 protein coding gene Chr5:133001899-133066790 (-)
AKR/J MGP_AKRJ_G0030058
 protein coding gene Chr5:137317100-137380896 (-)
BALB/cJ MGP_BALBcJ_G0030135
 protein coding gene Chr5:134336345-134402326 (-)
C3H/HeJ MGP_C3HHeJ_G0029851
 protein coding gene Chr5:137854745-137920969 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030588
 protein coding gene Chr5:144122121-144186753 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027812
 protein coding gene Chr5:127283454-127347694 (-)
CAST/EiJ MGP_CASTEiJ_G0029260
 protein coding gene Chr5:137291634-137361736 (-)
CBA/J MGP_CBAJ_G0029821
 protein coding gene Chr5:149739893-149813183 (-)
DBA/2J MGP_DBA2J_G0029972
 protein coding gene Chr5:132899304-132963088 (-)
FVB/NJ MGP_FVBNJ_G0029921
 protein coding gene Chr5:130129419-132096791 (-)
LP/J MGP_LPJ_G0030060
 protein coding gene Chr5:139374471-139441813 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029959
 protein coding gene Chr5:152821251-152886461 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030628
 protein coding gene Chr5:137038578-137104115 (-)
PWK/PhJ MGP_PWKPhJ_G0028975
 protein coding gene Chr5:131924719-131989344 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028810
 protein coding gene Chr5:134622264-134683721 (-)
WSB/EiJ MGP_WSBEiJ_G0029334
 protein coding gene Chr5:137790598-137858562 (-)



Homology
more
  • Human Ortholog
    CLIP2, CAP-Gly domain containing linker protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLIP2, CAP-Gly domain containing linker protein 2
  • Synonyms
    CLIP, CLIP-115, CYLN2, WBSCR3, WBSCR4, WSCR3, WSCR4
  • Links
    NCBI Gene ID: 7461
    neXtProt AC: NX_Q9UDT6
    UniProt: Q9UDT6

  • Chr Location
    7q11.23; chr7:74289407-74405935 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Clip2 mouse models

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous and heterozygous for disruptions in this gene display growth deficiency, brain abnormalities and hippocampal dysfunction and deficits in motor coordination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    946
  • Tissues
    49
  • cDNA Data
    95
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063146 Ensembl Gene Model | MGI Sequence Detail 63052 C57BL/6J ±  kb
    transcript ENSMUST00000100647 Ensembl | MGI Sequence Detail 4994 Not Applicable  
    polypeptide ENSMUSP00000098212 Ensembl | MGI Sequence Detail 1047 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005582 CAP-Gly domain-containing linker protein 2
      (term hierarchy)
    • InterPro Domains
      IPR000938 CAP Gly-rich domain
      IPR036859 CAP Gly-rich domain superfamily
    • GlyGen
      Q9Z0H8 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 105
      Genomic 6
      cDNA 96
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1196304
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 7
      Diseases 3
      Gene Ontology 6
      Phenotypes 21
    • Earliest
      J:45192 De Zeeuw CI, et al., CLIP-115, a novel brain-specific cytoplasmic linker protein, mediates the localization of dendritic lamellar bodies. Neuron. 1997 Dec;19(6):1187-99
    • Latest
      J:337436 Abdalla N, et al., Dysfunctional Mitochondria in the Cardiac Fibers of a Williams-Beuren Syndrome Mouse Model. Int J Mol Sci. 2023 Jun 13;24(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory