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Slfn2 Gene Detail
Summary
  • Symbol
    Slfn2
  • Name
    schlafen 2
  • Synonyms
    Shlf2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313258
    NCBI Gene: 20556
  • Alliance
    gene page
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:82955938-82961504 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 50.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1313258
 protein coding gene Chr11:82955938-82961504 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018839
 protein coding gene Chr11:84390086-84395735 (+)
A/J MGP_AJ_G0018806
 protein coding gene Chr11:81146045-81151764 (+)
AKR/J MGP_AKRJ_G0018776
 protein coding gene Chr11:83580749-83586361 (+)
BALB/cJ MGP_BALBcJ_G0018779
 protein coding gene Chr11:81560192-81566468 (+)
C3H/HeJ MGP_C3HHeJ_G0018593
 protein coding gene Chr11:83607547-83613945 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019231
 protein coding gene Chr11:86908432-86913908 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016865
 protein coding gene Chr11:78037754-78043482 (+)
CAST/EiJ MGP_CASTEiJ_G0018148
 protein coding gene Chr11:84220776-84226367 (+)
CBA/J MGP_CBAJ_G0018564
 protein coding gene Chr11:90702553-90710357 (+)
DBA/2J MGP_DBA2J_G0018672
 protein coding gene Chr11:80723755-80729690 (+)
FVB/NJ MGP_FVBNJ_G0018661
 protein coding gene Chr11:80237958-80244689 (+)
LP/J MGP_LPJ_G0018742
 protein coding gene Chr11:84884947-84891493 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018688
 protein coding gene Chr11:90875498-90882391 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019271
 protein coding gene Chr11:83853866-83861298 (+)
PWK/PhJ MGP_PWKPhJ_G0017918
 protein coding gene Chr11:81518673-81524540 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017709
 protein coding gene Chr11:83407605-83414229 (+)
WSB/EiJ MGP_WSBEiJ_G0018199
 protein coding gene Chr11:83692105-83698667 (+)



Homology
more
  • Human Ortholog
    SLFN12, schlafen family member 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLFN12, schlafen family member 12
  • Synonyms
    SLFN3
  • Links
    NCBI Gene ID: 55106
    neXtProt AC: NX_Q8IYM2
    UniProt: Q8IYM2

  • Chr Location
    17q12; chr17:35409465-35433475 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit increased susceptibility to bacterial and viral infections, reduced T cell numbers, decreased T cell proliferation, and increased apoptosis of activated T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    1
  • cDNA Data
    17
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20556 NCBI Gene Model | MGI Sequence Detail 5567 C57BL/6J ±  kb
    transcript NM_011408 RefSeq | MGI Sequence Detail 1684 Not Specified  
    polypeptide Q9Z0I6 UniProt | EBI | MGI Sequence Detail 378 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR031450 Poxin-Schlafen/Schlafen-like, N-terminal domain
      IPR007421 Schlafen, AlbA_2 domain
      IPR038461 Schlafen, AlbA_2 domain superfamily
      IPR029684 Schlafen family
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 4
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:344312 Liu H, et al., Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development. iScience. 2024 Jan 19;27(1):108722
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory