Slfn1 MGI Mouse Gene Detail - MGI:1313259

Symbol

Slfn1
Name

schlafen 1

Feature Type

protein coding gene
IDs

MGI:1313259
NCBI Gene: 20555
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:83007675-83013496 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 50.30 cM
Mapping Data

4 experiments

SNPs within 2kb

214 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1313259	protein coding gene	Chr11:83007646-83013496 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018840	protein coding gene	Chr11:84427282-84433103 (+)
A/J	MGP_AJ_G0018807	protein coding gene	Chr11:81203104-81208925 (+)
AKR/J	MGP_AKRJ_G0018777	protein coding gene	Chr11:83614927-83620747 (+)
BALB/cJ	MGP_BALBcJ_G0018780	protein coding gene	Chr11:81614630-81620451 (+)
C3H/HeJ	MGP_C3HHeJ_G0018594	protein coding gene	Chr11:83664012-83669833 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019232	protein coding gene	Chr11:86976960-86982781 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016866	protein coding gene	Chr11:78065623-78071493 (+)
CAST/EiJ	MGP_CASTEiJ_G0018149	protein coding gene	Chr11:84261534-84267356 (+)
CBA/J	MGP_CBAJ_G0018565	protein coding gene	Chr11:90772112-90777933 (+)
DBA/2J	MGP_DBA2J_G0018673	protein coding gene	Chr11:80782533-80788354 (+)
FVB/NJ	MGP_FVBNJ_G0018662	protein coding gene	Chr11:80293044-80298865 (+)
LP/J	MGP_LPJ_G0018743	protein coding gene	Chr11:84928128-84933949 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018689	protein coding gene	Chr11:90931946-90937767 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019272	protein coding gene	Chr11:83904917-83910724 (+)
PWK/PhJ	MGP_PWKPhJ_G0017919	protein coding gene	Chr11:81575043-81580864 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017710	protein coding gene	Chr11:83442232-83448039 (+)
WSB/EiJ	MGP_WSBEiJ_G0018200	protein coding gene	Chr11:83752589-83758410 (+)

Human Ortholog

SLFN12, schlafen family member 12

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLFN12, schlafen family member 12
Synonyms

SLFN3
Links

HGNC:25500

NCBI Gene ID: 55106

neXtProt AC: NX_Q8IYM2

UniProt: Q8IYM2
Chr Location

17q12; chr17:35409465-35433475 (-) GRCh38

Human Ortholog

SLFN12L, schlafen family member 12 like
Links

HGNC:33920

NCBI Gene ID: 100506736

neXtProt AC: NX_Q6IEE8

UniProt: Q6IEE8
Chr Location

17

MGI Vertebrate Homology

Slfn1 stringent orthology
2 human;1 mouse
HCOP

vertebrate homology predictions: SLFN12, SLFN12L
Gene Tree

Slfn1

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Phenotype Summary

5 phenotypes from 3 alleles in 4 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

5
Genomic Mutations

2 involving Slfn1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show normal thymus cellularity and expression of cell surface markers on thymocytes and peripheral lymphocytes. Mice homozygous for a different null allele show normal immune cell populations and MOG-induced experimental autoimmune encephalitis development.

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All GO Annotations

16
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

17
cDNA Data

24
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS25157.1

Ensembl

ENSMUSG00000078763 (Evidence)
NCBI Gene

20555

			Length	Strain/Species	Flank
genomic	ENSMUSG00000078763	Ensembl Gene Model \| MGI Sequence Detail	5822	C57BL/6J	± kb
transcript	ENSMUST00000037994	Ensembl \| MGI Sequence Detail	1864	Not Applicable
polypeptide	ENSMUSP00000047782	Ensembl \| MGI Sequence Detail	337	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR031450 Poxin-Schlafen/Schlafen-like, N-terminal domain

IPR007421 Schlafen, AlbA_2 domain

IPR038461 Schlafen, AlbA_2 domain superfamily

IPR029684 Schlafen family
GlyGen

Q9Z0I7 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 24

cDNA 24

Microarray probesets 3

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MGI:2144470

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 18
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slfn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103652	Chr11:83007506-83007515 (+)	-164 bp
Tssr103653	Chr11:83007614-83007623 (+)	-56 bp
Tssr103654	Chr11:83007635-83007676 (+)	-19 bp
Tssr103655	Chr11:83007694-83007708 (+)	26 bp
Tssr103656	Chr11:83007739-83007744 (+)	67 bp
Tssr103657	Chr11:83007778-83007794 (+)	111 bp
Tssr103658	Chr11:83007800-83007825 (+)	138 bp
Tssr103659	Chr11:83007829-83007847 (+)	163 bp
Tssr103660	Chr11:83009155-83009184 (+)	1,495 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24