Oc90 MGI Mouse Gene Detail - MGI:1313269

Symbol

Oc90
Name

otoconin 90
Synonyms

Ocn-95, PLA2L, Pla2ll

Feature Type

protein coding gene
IDs

MGI:1313269
NCBI Gene: 18256
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:65747902-65784246 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 29.16 cM
Mapping Data

7 experiments

SNPs within 2kb

1333 from dbSNP Build 142
Strain Annotations

18
PCR

2
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1313269	protein coding gene	Chr15:65747899-65784260 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021901	protein coding gene	Chr15:65373149-65417682 (-)
A/J	MGP_AJ_G0021860	protein coding gene	Chr15:62876770-62912370 (-)
AKR/J	MGP_AKRJ_G0021842	protein coding gene	Chr15:64636522-64674530 (-)
BALB/cJ	MGP_BALBcJ_G0021867	protein coding gene	Chr15:63065524-63103770 (-)
C3H/HeJ	MGP_C3HHeJ_G0021640	protein coding gene	Chr15:64746692-64785572 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022306	protein coding gene	Chr15:67897664-67957295 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019843	protein coding gene	Chr15:59699962-59734308 (-)
CAST/EiJ	MGP_CASTEiJ_G0021159	protein coding gene	Chr15:65403090-65436892 (-)
CBA/J	MGP_CBAJ_G0021606	protein coding gene	Chr15:70196366-70230624 (-)
DBA/2J	MGP_DBA2J_G0021731	protein coding gene	Chr15:62679092-62715520 (-)
FVB/NJ	MGP_FVBNJ_G0021713	protein coding gene	Chr15:61718884-61754934 (-)
LP/J	MGP_LPJ_G0021803	protein coding gene	Chr15:65258434-65299718 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021736	protein coding gene	Chr15:75278934-75317202 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022328	protein coding gene	Chr15:65009995-65046732 (-)
PWK/PhJ	MGP_PWKPhJ_G0020900	protein coding gene	Chr15:62765666-62801083 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020741	protein coding gene	Chr15:64863996-64899644 (-)
WSB/EiJ	MGP_WSBEiJ_G0021211	protein coding gene	Chr15:64987077-65023259 (-)

Human Ortholog

OC90, otoconin 90

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OC90, otoconin 90
Synonyms

PLA2L
Links

HGNC:8100

NCBI Gene ID: 729330

neXtProt AC: NX_Q02509

UniProt: Q02509
Chr Location

8q24.22

MGI Vertebrate Homology

Oc90 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: OC90
Gene Tree

Oc90

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

3
Endonuclease-mediated

2
Radiation induced

4
Targeted

4
Genomic Mutations

7 involving Oc90
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced, enlarged, and loose otoliths, and thin cupula, saccule, utricle and tectorial membranes.

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

828
Tissues

41
cDNA Data

15
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase oc90

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All Sequences

61
RefSeq

18
UniProt

4
CCDS

CCDS27508.1, CCDS84171.1

Ensembl

ENSMUSG00000015001 (Evidence)
NCBI Gene

18256

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015001	Ensembl Gene Model \| MGI Sequence Detail	36345	C57BL/6J	± kb
transcript	ENSMUST00000060522	Ensembl \| MGI Sequence Detail	1909	Not Applicable
polypeptide	ENSMUSP00000062865	Ensembl \| MGI Sequence Detail	485	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011589 otoconin-90

(term hierarchy)
InterPro Domains

IPR041798 Otoconin-90, phospholipase A2-like domain

IPR001211 Phospholipase A2

IPR033112 Phospholipase A2, aspartic acid active site

IPR016090 Phospholipase A2 domain

IPR036444 Phospholipase A2 domain superfamily

IPR033113 Phospholipase A2, histidine active site
GlyGen

Q9Z0L3 4 sites

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All nucleic 26

Genomic 3

cDNA 17

Primer pair 6

Microarray probesets 4

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MGD-MRK-38290, MGI:109245

Summaries

All 72

Developmental Gene Expression 14

Diseases 1

Gene Ontology 8

Phenotypes 31
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:332093 Szeto IYY, et al., SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2122121119

TSS for Oc90:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134555	Chr15:65784268-65784286 (-)	-31 bp
Tssr134554	Chr15:65784196-65784206 (-)	45 bp
Tssr134553	Chr15:65784134-65784141 (-)	108 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24