Usp9y MGI Mouse Gene Detail - MGI:1313274 - ubiquitin specific peptidase 9, Y chromosome

Usp9y Gene Detail

Symbol

Usp9y
Name

ubiquitin specific peptidase 9, Y chromosome
Synonyms

Dffry, Fafl2

Feature Type

protein coding gene
IDs

MGI:1313274
NCBI Gene: 107868
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

ChrY:1298961-1459782 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome Y, cytoband p
Mapping Data

3 experiments

SNPs within 2kb

138 from dbSNP Build 142
Strain Annotations

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1313274	protein coding gene	ChrY:1298961-1459782 (-)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

USP9Y, ubiquitin specific peptidase 9 Y-linked

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

USP9Y, ubiquitin specific peptidase 9 Y-linked
Synonyms

DFFRY, FAF-Y, SPGFY2
Links

HGNC:12633

NCBI Gene ID: 8287

neXtProt AC: NX_O00507

UniProt: O00507
Chr Location

Yq11.221; chrY:12537650-12860839 (+) GRCh38

MGI Vertebrate Homology

Usp9y stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: USP9Y
Gene Tree

Usp9y

Diseases

1 with human USP9Y associations

				Human Disease	Mouse Models
				Y-linked spermatogenic failure 2 IDs Y-linked spermatogenic failure 2 DOID:0070187 MESH:C564030 OMIM:415000

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotype references

All Mutations and Alleles

4
Targeted

2
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

89 strains or lines available

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

20
cDNA Data

1
Literature Summary

6

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

ZFIN usp9

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All Sequences

10
RefSeq

2
UniProt

2
CCDS

CCDS30544.1

Ensembl

ENSMUSG00000069044 (Evidence)
NCBI Gene

107868

			Length	Strain/Species	Flank
genomic	107868	NCBI Gene Model \| MGI Sequence Detail	160822	C57BL/6J	± kb
transcript	NM_148943	RefSeq \| MGI Sequence Detail	8094	Not Specified
polypeptide	F8VPU6	UniProt \| EBI \| MGI Sequence Detail	2556	Not Applicable

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UniProt

2 Sequences
EC

3.4.19.12
InterPro Domains

IPR016024 Armadillo-type fold

IPR038765 Papain-like cysteine peptidase superfamily

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase

IPR050164 Ubiquitin carboxyl-terminal hydrolases

IPR021905 Ubiquitin C-terminal hydrolase-like, DUF3517

IPR018200 Ubiquitin specific protease, conserved site

IPR028889 Ubiquitin specific protease domain
GlyGen

F8VPU6 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 7

Genomic 3

cDNA 1

Primer pair 3

Microarray probesets 2

Summaries

All 30

Developmental Gene Expression 6

Gene Ontology 6

Phenotypes 4
Earliest

J:45388 Brown GM, et al., Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene. Hum Mol Genet. 1998 Jan;7(1):97-107
Latest

J:246359 Kuroki S, et al., Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance. PLoS Genet. 2017 Sep;13(9):e1007034

TSS for Usp9y:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164670	ChrY:1459771-1459782 (-)	5 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24