crsp Gene Detail

Summary

• Symbol
  crsp
• Name
  cryptorchidism with white spotting, deletion region

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:1313307
  NCBI Gene: 12948
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 5, Syntenic
• Mapping Data
  2 experiments

Strain
Comparison

• PCR
  1

Human Diseases

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  11 phenotypes from 1 allele in 2 genetic backgrounds
  13 phenotypes from multigenic genotypes
  10 phenotype references
  

• All Mutations and Alleles
  1
• Transgenic
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a deletion caused by random insertion of a tyrosinase expressing transgene exhibit partial postnatal lethality, variable white spotting, cryptorchism, arrest of spermatogenesis, azoospermia, and male infertility.

Expression

• cDNA Data
  1

Sequences &
Gene Models

• NCBI Gene
  12948

Molecular
Reagents

• All nucleic 2

  cDNA 1

  Primer pair 1

References

• Summaries
  All 14

  Diseases 1

  Phenotypes 10
• Earliest
  J:134392 Zhao S, et al., Tyrosinase-related protein 2 promoter targets transgene expression to ocular and neural crest-derived tissues. Dev Biol. 1999 Dec 1;216(1):154-63
• Latest
  J:209034 Ferguson L, et al., The fate of spermatogonial stem cells in the cryptorchid testes of RXFP2 deficient mice. PLoS One. 2013;8(10):e77351