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Rasgrp1 Gene Detail
Summary
  • Symbol
    Rasgrp1
  • Name
    RAS guanyl releasing protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314635
    NCBI Gene: 19419
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:117110464-117173358 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.19 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1817 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1314635
 protein coding gene Chr2:117110464-117173482 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026310
 protein coding gene Chr2:119919236-119987645 (-)
A/J MGP_AJ_G0026271
 protein coding gene Chr2:115042224-115106994 (-)
AKR/J MGP_AKRJ_G0026250
 protein coding gene Chr2:118254664-118318669 (-)
BALB/cJ MGP_BALBcJ_G0026284
 protein coding gene Chr2:115295199-115359364 (-)
C3H/HeJ MGP_C3HHeJ_G0026030
 protein coding gene Chr2:118687946-118754051 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026731
 protein coding gene Chr2:123859747-123927757 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024111
 protein coding gene Chr2:110115144-110178668 (-)
CAST/EiJ MGP_CASTEiJ_G0025492
 protein coding gene Chr2:119011765-119075662 (-)
CBA/J MGP_CBAJ_G0026006
 protein coding gene Chr2:128227199-128292379 (-)
DBA/2J MGP_DBA2J_G0026145
 protein coding gene Chr2:114468833-114532171 (-)
FVB/NJ MGP_FVBNJ_G0026107
 protein coding gene Chr2:113298368-113363129 (-)
LP/J MGP_LPJ_G0026246
 protein coding gene Chr2:120234026-120303160 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026126
 protein coding gene Chr2:132649401-132714413 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026786
 protein coding gene Chr2:118365993-118433093 (-)
PWK/PhJ MGP_PWKPhJ_G0025228
 protein coding gene Chr2:114027685-114091405 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025027
 protein coding gene Chr2:117487877-117554046 (-)
WSB/EiJ MGP_WSBEiJ_G0025561
 protein coding gene Chr2:119185908-119253448 (-)



Homology
more
  • Human Ortholog
    RASGRP1, RAS guanyl releasing protein 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASGRP1, RAS guanyl releasing protein 1
  • Synonyms
    CALDAG-GEFI, CALDAG-GEFII, IMD64, RASGRP
  • Links
    NCBI Gene ID: 10125
    neXtProt AC: NX_O95267
    UniProt: O95267

  • Chr Location
    15q14; chr15:38488103-38565575 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rasgrp1 mouse models; 1 with human RASGRP1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 10 alleles in 12 genetic backgrounds
    8 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for spontaneous and targeted null mutations exhibit a lymphoproliferative autoimmune syndrome in which T cells fail to activate Ras or proliferate after antigen exposure, defects in positive selection, and enlarged spleen and lymph nodes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    10
  • cDNA Data
    39
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19419 NCBI Gene Model | MGI Sequence Detail 62895 C57BL/6J ±  kb
    transcript NM_011246 RefSeq | MGI Sequence Detail 5129 ZRU/MplStud  
    polypeptide Q9Z1S3 UniProt | EBI | MGI Sequence Detail 795 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013758 RAS guanyl-releasing protein 1
      (term hierarchy)
    • InterPro Domains
      IPR046349 C1-like domain superfamily
      IPR020454 Diacylglycerol/phorbol-ester binding
      IPR018247 EF-Hand 1, calcium-binding site
      IPR002048 EF-hand domain
      IPR011992 EF-hand domain pair
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR008937 Ras-like guanine nucleotide exchange factor
      IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 1
      cDNA 41
      Primer pair 2

      Microarray probesets 7
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 9
      Phenotypes 59
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:342476 Chang Y, et al., Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling. J Immunol. 2023 Sep 15;211(6):917-922
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory