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Spsb2 Gene Detail
Summary
  • Symbol
    Spsb2
  • Name
    splA/ryanodine receptor domain and SOCS box containing 2
  • Synonyms
    Grcc9, SSB2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315199
    NCBI Gene: 14794
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124785640-124787582 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1315199
 protein coding gene Chr6:124785624-124787582 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031268
 protein coding gene Chr6:128115448-128117406 (+)
A/J MGP_AJ_G0031238
 protein coding gene Chr6:123293969-123295927 (+)
AKR/J MGP_AKRJ_G0031166
 protein coding gene Chr6:126658442-126660400 (+)
BALB/cJ MGP_BALBcJ_G0031246
 protein coding gene Chr6:122894538-122896541 (+)
C3H/HeJ MGP_C3HHeJ_G0030969
 protein coding gene Chr6:126705134-126707092 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031702
 protein coding gene Chr6:131499133-131501099 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028852
 protein coding gene Chr6:120504948-120506918 (+)
CAST/EiJ MGP_CASTEiJ_G0030350
 protein coding gene Chr6:126908608-126910565 (+)
CBA/J MGP_CBAJ_G0030930
 protein coding gene Chr6:136529466-136531424 (+)
DBA/2J MGP_DBA2J_G0031086
 protein coding gene Chr6:122220823-122223508 (+)
FVB/NJ MGP_FVBNJ_G0031036
 protein coding gene Chr6:121123554-121125512 (+)
LP/J MGP_LPJ_G0031166
 protein coding gene Chr6:128285577-128287542 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031074
 protein coding gene Chr6:140589751-140591709 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031737
 protein coding gene Chr6:126552012-126553969 (+)
PWK/PhJ MGP_PWKPhJ_G0030065
 protein coding gene Chr6:120449773-120451774 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029894
 protein coding gene Chr6:124632130-124634087 (+)
WSB/EiJ MGP_WSBEiJ_G0030435
 protein coding gene Chr6:126911989-126913945 (+)



Homology
more
  • Human Ortholog
    SPSB2, splA/ryanodine receptor domain and SOCS box containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPSB2, splA/ryanodine receptor domain and SOCS box containing 2
  • Synonyms
    GRCC9, SSB2
  • Links
    NCBI Gene ID: 84727
    neXtProt AC: NX_Q99619
    UniProt: Q99619

  • Chr Location
    12p13.31; chr12:6870935-6889358 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit mild thrombocytopenia and decreased blood urea nitrogen levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    42
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14794 NCBI Gene Model | MGI Sequence Detail 1943 C57BL/6J ±  kb
    transcript NM_013539 RefSeq | MGI Sequence Detail 1217 ZRU/MplStud  
    polypeptide O88838 UniProt | EBI | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 1
      cDNA 42

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141421
    References
    more
    • Summaries
      All 38
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:45711 Ansari-Lari MA, et al., Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res. 1998 Jan;8(1):29-40
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory