M1ap MGI Mouse Gene Detail - MGI:1315200 - meiosis 1 associated protein

Symbol

M1ap
Name

meiosis 1 associated protein
Synonyms

D6Mm5e

Feature Type

protein coding gene
IDs

MGI:1315200
NCBI Gene: 110958
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr6:82923889-83007290 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 35.94 cM
Mapping Data

2 experiments

SNPs within 2kb

400 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1315200	protein coding gene	Chr6:82923883-83007290 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030908	protein coding gene	Chr6:83939085-84032988 (+)
A/J	MGP_AJ_G0030877	protein coding gene	Chr6:80735720-80819030 (+)
AKR/J	MGP_AKRJ_G0030805	protein coding gene	Chr6:83062989-83150133 (+)
BALB/cJ	MGP_BALBcJ_G0030887	protein coding gene	Chr6:80749608-80833411 (+)
C3H/HeJ	MGP_C3HHeJ_G0030823	protein coding gene	Chr6:101233377-101319377 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031347	protein coding gene	Chr6:86220046-86312464 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028533	protein coding gene	Chr6:79086005-79179115 (+)
CAST/EiJ	MGP_CASTEiJ_G0029996	protein coding gene	Chr6:83061478-83148370 (+)
CBA/J	MGP_CBAJ_G0030574	protein coding gene	Chr6:89635131-89725779 (+)
DBA/2J	MGP_DBA2J_G0030727	protein coding gene	Chr6:80055497-80140412 (+)
FVB/NJ	MGP_FVBNJ_G0030680	protein coding gene	Chr6:79263175-79347214 (+)
LP/J	MGP_LPJ_G0030806	protein coding gene	Chr6:83932948-84025900 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030716	protein coding gene	Chr6:93940132-94028876 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031371	protein coding gene	Chr6:82877211-82962501 (+)
PWK/PhJ	MGP_PWKPhJ_G0029711	protein coding gene	Chr6:78946658-79031157 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029539	protein coding gene	Chr6:81720692-81806696 (+)
WSB/EiJ	MGP_WSBEiJ_G0030077	protein coding gene	Chr6:83315268-83402494 (+)

Human Ortholog

M1AP, meiosis 1 associated protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

M1AP, meiosis 1 associated protein
Synonyms

C2orf65, D6Mm5e, SPATA37, SPGF48
Links

HGNC:25183

NCBI Gene ID: 130951

neXtProt AC: NX_Q8TC57

UniProt: Q8TC57
Chr Location

2p13.1; chr2:74557883-74648338 (-) GRCh38

MGI Vertebrate Homology

M1ap stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: M1AP
Gene Tree

M1ap

Diseases

1 with human M1AP associations

				Human Disease	Mouse Models
				spermatogenic failure 48 IDs spermatogenic failure 48 DOID:0112176 OMIM:619108

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Gene trapped

1
Spontaneous

1
Targeted

2
Genomic Mutations

2 involving M1ap
Incidental Mutations

APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit male infertility with oligospermia, globozooaspermiam decreased testies weight and size, degeneration of seminiferous tubules, male germ cell apoptosis and arrested male meiosis.

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All GO Annotations

16
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

838
Tissues

80
cDNA Data

9
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase m1ap

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All Sequences

43
RefSeq

8
UniProt

2
CCDS

CCDS39525.1

Ensembl

ENSMUSG00000030041 (Evidence)
NCBI Gene

110958

			Length	Strain/Species	Flank
genomic	110958	NCBI Gene Model \| MGI Sequence Detail	83402	C57BL/6J	± kb
transcript	NM_033079	RefSeq \| MGI Sequence Detail	2051	ZRU/MplStud
polypeptide	Q9Z0E1	UniProt \| EBI \| MGI Sequence Detail	529	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000059974 meiosis 1 arrest protein

(term hierarchy)
InterPro Domains

IPR033587 Meiosis 1 arrest protein

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All nucleic 25

Genomic 10

cDNA 9

Primer pair 3

Other 3

Microarray probesets 2

Summaries

All 37

Developmental Gene Expression 5

Gene Ontology 9

Phenotypes 11
Earliest

J:50420 Weber JS, et al., High-resolution genetic, physical, and transcript map of the mnd2 region of mouse chromosome 6. Genomics. 1998 Nov 15;54(1):107-15
Latest

J:347973 Li Y, et al., M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination. EMBO Rep. 2023 Feb 6;24(2):e55778

TSS for M1ap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57261	Chr6:82923879-82923905 (+)	3 bp
Tssr57263	Chr6:82937190-82937199 (+)	13,306 bp
Tssr57264	Chr6:82937222-82937233 (+)	13,339 bp
Tssr57265	Chr6:82937250-82937259 (+)	13,366 bp
Tssr57266	Chr6:82937521-82937528 (+)	13,636 bp
Tssr57267	Chr6:82975810-82975811 (+)	51,922 bp
Tssr57268	Chr6:82982827-82982854 (+)	58,952 bp
Tssr57269	Chr6:82983241-82983262 (+)	59,363 bp
Tssr57270	Chr6:82985898-82985912 (+)	62,016 bp
Tssr57271	Chr6:82991674-82991678 (+)	67,787 bp
Tssr57272	Chr6:82992259-82992298 (+)	68,390 bp
Tssr57273	Chr6:83003253-83003286 (+)	79,381 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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