About   Help   FAQ
M1ap Gene Detail
Summary
  • Symbol
    M1ap
  • Name
    meiosis 1 associated protein
  • Synonyms
    D6Mm5e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315200
    NCBI Gene: 110958
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:82923889-83007290 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    400 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1315200
 protein coding gene Chr6:82923883-83007290 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030908
 protein coding gene Chr6:83939085-84032988 (+)
A/J MGP_AJ_G0030877
 protein coding gene Chr6:80735720-80819030 (+)
AKR/J MGP_AKRJ_G0030805
 protein coding gene Chr6:83062989-83150133 (+)
BALB/cJ MGP_BALBcJ_G0030887
 protein coding gene Chr6:80749608-80833411 (+)
C3H/HeJ MGP_C3HHeJ_G0030823
 protein coding gene Chr6:101233377-101319377 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031347
 protein coding gene Chr6:86220046-86312464 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028533
 protein coding gene Chr6:79086005-79179115 (+)
CAST/EiJ MGP_CASTEiJ_G0029996
 protein coding gene Chr6:83061478-83148370 (+)
CBA/J MGP_CBAJ_G0030574
 protein coding gene Chr6:89635131-89725779 (+)
DBA/2J MGP_DBA2J_G0030727
 protein coding gene Chr6:80055497-80140412 (+)
FVB/NJ MGP_FVBNJ_G0030680
 protein coding gene Chr6:79263175-79347214 (+)
LP/J MGP_LPJ_G0030806
 protein coding gene Chr6:83932948-84025900 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030716
 protein coding gene Chr6:93940132-94028876 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031371
 protein coding gene Chr6:82877211-82962501 (+)
PWK/PhJ MGP_PWKPhJ_G0029711
 protein coding gene Chr6:78946658-79031157 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029539
 protein coding gene Chr6:81720692-81806696 (+)
WSB/EiJ MGP_WSBEiJ_G0030077
 protein coding gene Chr6:83315268-83402494 (+)



Homology
more
  • Human Ortholog
    M1AP, meiosis 1 associated protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    M1AP, meiosis 1 associated protein
  • Synonyms
    C2orf65, D6Mm5e, SPATA37, SPGF48
  • Links
    NCBI Gene ID: 130951
    neXtProt AC: NX_Q8TC57
    UniProt: Q8TC57

  • Chr Location
    2p13.1; chr2:74557883-74648338 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human M1AP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit male infertility with oligospermia, globozooaspermiam decreased testies weight and size, degeneration of seminiferous tubules, male germ cell apoptosis and arrested male meiosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    80
  • cDNA Data
    9
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110958 NCBI Gene Model | MGI Sequence Detail 83402 C57BL/6J ±  kb
    transcript NM_033079 RefSeq | MGI Sequence Detail 2051 ZRU/MplStud  
    polypeptide Q9Z0E1 UniProt | EBI | MGI Sequence Detail 529 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 10
      cDNA 9
      Primer pair 3
      Other 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:50420 Weber JS, et al., High-resolution genetic, physical, and transcript map of the mnd2 region of mouse chromosome 6. Genomics. 1998 Nov 15;54(1):107-15
    • Latest
      J:347973 Li Y, et al., M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination. EMBO Rep. 2023 Feb 6;24(2):e55778
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory