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Slit3 Gene Detail
Summary
  • Symbol
    Slit3
  • Name
    slit guidance ligand 3
  • Synonyms
    b2b2362.1Clo, Slit1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315202
    NCBI Gene: 20564
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:35012283-35599334 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 20.29 cM, cytoband A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    17730 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1315202
 protein coding gene Chr11:35012051-35599334 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018154
 protein coding gene Chr11:33488084-34110459 (+)
A/J MGP_AJ_G0018127
 protein coding gene Chr11:32240600-32833028 (+)
AKR/J MGP_AKRJ_G0018091
 protein coding gene Chr11:33217838-33819812 (+)
BALB/cJ MGP_BALBcJ_G0018096
 protein coding gene Chr11:32406213-32997844 (+)
C3H/HeJ MGP_C3HHeJ_G0017909
 protein coding gene Chr11:33164551-33778855 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018550
 protein coding gene Chr11:34513587-35150748 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016205
 protein coding gene Chr11:30702792-31289708 (+)
CAST/EiJ MGP_CASTEiJ_G0017473
 protein coding gene Chr11:33150758-33765108 (+)
CBA/J MGP_CBAJ_G0017882
 protein coding gene Chr11:36223645-36836443 (+)
DBA/2J MGP_DBA2J_G0017992
 protein coding gene Chr11:31989029-32579112 (+)
FVB/NJ MGP_FVBNJ_G0017986
 protein coding gene Chr11:31826192-32429497 (+)
LP/J MGP_LPJ_G0018064
 protein coding gene Chr11:33712526-34322354 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018010
 protein coding gene Chr11:36951436-37563623 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018589
 protein coding gene Chr11:33240412-33840629 (+)
PWK/PhJ MGP_PWKPhJ_G0017254
 protein coding gene Chr11:32064908-32665347 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017046
 protein coding gene Chr11:33004444-33618646 (+)
WSB/EiJ MGP_WSBEiJ_G0017522
 protein coding gene Chr11:33006175-33620684 (+)



Homology
more
  • Human Ortholog
    SLIT3, slit guidance ligand 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLIT3, slit guidance ligand 3
  • Synonyms
    MEGF5, SLIL2, SLIT1, slit2, Slit-3
  • Links
    NCBI Gene ID: 6586
    neXtProt AC: NX_O75094
    UniProt: O75094

  • Chr Location
    5q34-q35.1; chr5:168661740-169301139 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slit3 mouse models

Human Disease Mouse Models
      
IDs
 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 4 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    14 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele show congenital diaphragmatic hernia (CDH), variable renal defects and enlarged heart right ventricles. Mice homozygous for either of two reporter alleles show diaphragm dysgenesis and die prematurely; those with end-stage CDH show dyspnea and lung congestion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1043
  • Tissues
    242
  • cDNA Data
    14
  • Literature Summary
    72
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20564 NCBI Gene Model | MGI Sequence Detail 587052 C57BL/6J ±  kb
    transcript NM_011412 RefSeq | MGI Sequence Detail 5017 C57BL/6  
    polypeptide Q9WVB4 UniProt | EBI | MGI Sequence Detail 1523 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000015236 slit homolog 3 protein
      (term hierarchy)
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR006207 Cystine knot, C-terminal
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR013032 EGF-like, conserved site
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR001791 Laminin G domain
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR000372 Leucine-rich repeat N-terminal domain
      IPR003591 Leucine-rich repeat, typical subtype
      IPR051355 Notch and Slit guidance protein
    • GlyGen
      Q9WVB4 13 sites, 7 N-linked glycans (7 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 20
      Primer pair 8
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:5560151
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 72
      Diseases 3
      Gene Ontology 10
      Phenotypes 49
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:354049 Pulcrano S, et al., miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network. J Neurosci. 2023 Nov 29;43(48):8104-8125
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory