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Slc40a1 Gene Detail
Summary
  • Symbol
    Slc40a1
  • Name
    solute carrier family 40 (iron-regulated transporter), member 1
  • Synonyms
    Dusg, ferroportin1, FPN1, IREG1, metal transporting protein 1, MTP1, Ol5, Pcm, Slc11a3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315204
    NCBI Gene: 53945
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:45947228-45965683 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 23.96 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    644 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1315204
 protein coding gene Chr1:45947228-45965690 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015996
 protein coding gene Chr1:44992735-45011143 (-)
A/J MGP_AJ_G0015980
 protein coding gene Chr1:43590526-43609059 (-)
AKR/J MGP_AKRJ_G0015935
 protein coding gene Chr1:44225788-44244307 (-)
BALB/cJ MGP_BALBcJ_G0015934
 protein coding gene Chr1:43220049-43238395 (-)
C3H/HeJ MGP_C3HHeJ_G0015767
 protein coding gene Chr1:44638555-44657087 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016387
 protein coding gene Chr1:46869053-46888658 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014110
 protein coding gene Chr1:40268690-40287321 (-)
CAST/EiJ MGP_CASTEiJ_G0015349
 protein coding gene Chr1:44528389-44547553 (-)
CBA/J MGP_CBAJ_G0015739
 protein coding gene Chr1:48200391-48221512 (-)
DBA/2J MGP_DBA2J_G0015840
 protein coding gene Chr1:42868091-42886894 (-)
FVB/NJ MGP_FVBNJ_G0015842
 protein coding gene Chr1:42324494-42342906 (-)
LP/J MGP_LPJ_G0015910
 protein coding gene Chr1:45288390-45309134 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015862
 protein coding gene Chr1:50327752-50348326 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016434
 protein coding gene Chr1:44436753-44456423 (-)
PWK/PhJ MGP_PWKPhJ_G0015133
 protein coding gene Chr1:42673117-42692122 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014915
 protein coding gene Chr1:44447061-44466838 (-)
WSB/EiJ MGP_WSBEiJ_G0015410
 protein coding gene Chr1:44410223-44429922 (-)



Homology
more
  • Human Ortholog
    SLC40A1, solute carrier family 40 member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC40A1, solute carrier family 40 member 1
  • Synonyms
    FPN, FPN1, HFE4, IREG1, MST079, MSTP079, MTP1, SLC11A3
  • Links
    NCBI Gene ID: 30061
    neXtProt AC: NX_Q9NP59
    UniProt: Q9NP59

  • Chr Location
    2q32.2; chr2:189560590-189583758 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc40a1 mouse models; 1 with human SLC40A1 associations

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    71 phenotypes from 7 alleles in 9 genetic backgrounds
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation exhibit embryonic lethality before embryo turning. Mice heterozygous for a targeted mutation display decreased thermal response latency. Mice heterozygous for an ENU induced mutation display abnormal iron homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1054
  • Tissues
    134
  • cDNA Data
    65
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025993 Ensembl Gene Model | MGI Sequence Detail 18456 C57BL/6J ±  kb
    transcript ENSMUST00000027137 Ensembl | MGI Sequence Detail 3370 Not Applicable  
    polypeptide ENSMUSP00000027137 Ensembl | MGI Sequence Detail 570 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 1
      cDNA 66
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1860151, MGI:700182
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 27
      Diseases 3
      Gene Ontology 18
      Phenotypes 64
    • Earliest
      J:49557 McKie AT, et al., Molecular cloning and characterisation of a novel duodenal-specific gene implicated in iron absorption. Biochem Soc Trans. 1998 Aug;26(3):S264
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory