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Nrip1 Gene Detail
Summary
  • Symbol
    Nrip1
  • Name
    nuclear receptor interacting protein 1
  • Synonyms
    6030458L20Rik, 8430438I05Rik, RIP140
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315213
    NCBI Gene: 268903
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:76084288-76170715 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 43.65 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2809 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1315213
 protein coding gene Chr16:76084288-76170930 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022956
 protein coding gene Chr16:76339666-76426703 (-)
A/J MGP_AJ_G0022924
 protein coding gene Chr16:72951892-73039123 (-)
AKR/J MGP_AKRJ_G0022894
 protein coding gene Chr16:75200867-75287225 (-)
BALB/cJ MGP_BALBcJ_G0022926
 protein coding gene Chr16:73361552-73448383 (-)
C3H/HeJ MGP_C3HHeJ_G0022688
 protein coding gene Chr16:75651995-75739198 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023374
 protein coding gene Chr16:78814407-78902742 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020877
 protein coding gene Chr16:71500851-71588089 (-)
CAST/EiJ MGP_CASTEiJ_G0022211
 protein coding gene Chr16:76012747-76102217 (-)
CBA/J MGP_CBAJ_G0022658
 protein coding gene Chr16:82159529-82249552 (-)
DBA/2J MGP_DBA2J_G0022791
 protein coding gene Chr16:72808482-72899801 (-)
FVB/NJ MGP_FVBNJ_G0022766
 protein coding gene Chr16:72188028-72275446 (-)
LP/J MGP_LPJ_G0022861
 protein coding gene Chr16:76113586-76202088 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022784
 protein coding gene Chr16:85271370-85360767 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023391
 protein coding gene Chr16:75520542-75607717 (-)
PWK/PhJ MGP_PWKPhJ_G0021953
 protein coding gene Chr16:73029760-73117963 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021783
 protein coding gene Chr16:75123796-75214025 (-)
WSB/EiJ MGP_WSBEiJ_G0022258
 protein coding gene Chr16:75705990-75796104 (-)



Homology
more
  • Human Ortholog
    NRIP1, nuclear receptor interacting protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRIP1, nuclear receptor interacting protein 1
  • Synonyms
    CAKUT3, RIP140
  • Links
    NCBI Gene ID: 8204
    neXtProt AC: NX_P48552
    UniProt: P48552

  • Chr Location
    21q11.2-q21.1; chr21:14961235-15065936 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human NRIP1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygosity for targeted disruption of this gene results in female infertility due to ovulation failure. Heterozygous females are partially affected. Male and female mice are smaller than wild-type littermates.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1055
  • Tissues
    213
  • cDNA Data
    18
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048490 Ensembl Gene Model | MGI Sequence Detail 86428 C57BL/6J ±  kb
    transcript ENSMUST00000054178 Ensembl | MGI Sequence Detail 4529 Not Applicable  
    polypeptide ENSMUSP00000051726 Ensembl | MGI Sequence Detail 1161 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000011427 nuclear receptor-interacting protein 1
      (term hierarchy)
    • InterPro Domains
      IPR026649 Nuclear receptor-interacting protein 1
      IPR031405 Nuclear receptor-interacting protein 1, repression domain 1
      IPR031406 Nuclear receptor-interacting protein 1, repression domain 2
      IPR031407 Nuclear receptor-interacting protein 1, repression domain 3
      IPR031408 Nuclear receptor-interacting protein 1, repression domain 4
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 23
      Primer pair 3
      Other 3

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1918801, MGI:1925132, MGI:2146368, MGI:2146638
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 20
      Phenotypes 40
    • Earliest
      J:46180 Katsanis N, et al., Localisation of receptor interacting protein 140 (RIP140) within 100 kb of D21S13 on 21q11, a gene-poor region of the human genome. Hum Genet. 1998 Feb;102(2):221-3
    • Latest
      J:335294 Redhead Y, et al., Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory