Sphk1 MGI Mouse Gene Detail - MGI:1316649

Symbol

Sphk1
Name

sphingosine kinase 1
Synonyms

1110006G24Rik, SK1

Feature Type

protein coding gene
IDs

MGI:1316649
NCBI Gene: 20698
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr11:116421751-116427501 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 81.42 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

192 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1316649	protein coding gene	Chr11:116421662-116427502 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019430	protein coding gene	Chr11:120665620-120671365 (+)
A/J	MGP_AJ_G0019398	protein coding gene	Chr11:115382786-115388533 (+)
AKR/J	MGP_AKRJ_G0019369	protein coding gene	Chr11:118817432-118823181 (+)
BALB/cJ	MGP_BALBcJ_G0019373	protein coding gene	Chr11:115782391-115788136 (+)
C3H/HeJ	MGP_C3HHeJ_G0019179	protein coding gene	Chr11:119174210-119179957 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019822	protein coding gene	Chr11:124347360-124353109 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017446	protein coding gene	Chr11:112381990-112387701 (+)
CAST/EiJ	MGP_CASTEiJ_G0018734	protein coding gene	Chr11:120549394-120555146 (+)
CBA/J	MGP_CBAJ_G0019150	protein coding gene	Chr11:129276971-129282718 (+)
DBA/2J	MGP_DBA2J_G0019262	protein coding gene	Chr11:114811730-114817475 (+)
FVB/NJ	MGP_FVBNJ_G0019254	protein coding gene	Chr11:114313861-114319606 (+)
LP/J	MGP_LPJ_G0019332	protein coding gene	Chr11:121048843-121054618 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019287	protein coding gene	Chr11:128314194-128319939 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019861	protein coding gene	Chr11:119482008-119487753 (+)
PWK/PhJ	MGP_PWKPhJ_G0018498	protein coding gene	Chr11:116135792-116141620 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018291	protein coding gene	Chr11:119230241-119235971 (+)
WSB/EiJ	MGP_WSBEiJ_G0018786	protein coding gene	Chr11:119445589-119453625 (+)

Human Ortholog

SPHK1, sphingosine kinase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPHK1, sphingosine kinase 1
Synonyms

SPHK
Links

HGNC:11240

NCBI Gene ID: 8877

neXtProt AC: NX_Q9NYA1

UniProt: Q9NYA1
Chr Location

17q25.1; chr17:76376584-76387860 (+) GRCh38

MGI Vertebrate Homology

Sphk1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SPHK1
Gene Tree

Sphk1

Diseases

1 with human SPHK1 associations

				Human Disease	Mouse Models
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

12 phenotypes from 4 alleles in 5 genetic backgrounds
35 phenotypes from multigenic genotypes
2 images
140 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

6
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are viable, fertile, and without any obvious abnormalities.

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All GO Annotations

115
GO References

20

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

735
Tissues

27
cDNA Data

50
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sphk1

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All Sequences

95
RefSeq

26
UniProt

8
CCDS

CCDS25668.1, CCDS25669.1, CCDS48986.1

Ensembl

ENSMUSG00000061878 (Evidence)
NCBI Gene

20698

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061878	Ensembl Gene Model \| MGI Sequence Detail	5751	C57BL/6J	± kb
transcript	ENSMUST00000141798	Ensembl \| MGI Sequence Detail	1537	Not Applicable
polypeptide	ENSMUSP00000131010	Ensembl \| MGI Sequence Detail	388	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000015522 sphingosine kinase 1

(term hierarchy)
EC

2.3.1.-, 2.7.1.91
InterPro Domains

IPR001206 Diacylglycerol kinase, catalytic domain

IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal

IPR050187 Lipid Phosphate Formation and Regulation

IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily

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All nucleic 57

cDNA 54

Primer pair 3

Microarray probesets 4

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MGI:1913372

Summaries

All 239

Developmental Gene Expression 14

Gene Ontology 20

Phenotypes 140
Earliest

J:49744 Kohama T, et al., Molecular cloning and functional characterization of murine sphingosine kinase. J Biol Chem. 1998 Sep 11;273(37):23722-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sphk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105960	Chr11:116421923-116421929 (+)	175 bp
Tssr105961	Chr11:116422652-116422668 (+)	909 bp
Tssr105962	Chr11:116422669-116422700 (+)	934 bp
Tssr105963	Chr11:116422712-116422722 (+)	966 bp
Tssr105964	Chr11:116422822-116422840 (+)	1,080 bp
Tssr105965	Chr11:116423248-116423251 (+)	1,499 bp
Tssr105966	Chr11:116423267-116423304 (+)	1,535 bp
Tssr3738	Chr11:116423324-116423327 (+)	1,575 bp
Tssr105967	Chr11:116423376-116423387 (+)	1,631 bp
Tssr105968	Chr11:116424083-116424101 (+)	2,341 bp
Tssr105969	Chr11:116424111-116424129 (+)	2,369 bp
Tssr105970	Chr11:116424788-116424798 (+)	3,042 bp
Tssr105971	Chr11:116424863-116424880 (+)	3,121 bp
Tssr105972	Chr11:116424884-116424895 (+)	3,139 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24