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Slc37a4 Gene Detail
Summary
  • Symbol
    Slc37a4
  • Name
    solute carrier family 37 (glucose-6-phosphate transporter), member 4
  • Synonyms
    G6PT, G6pt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316650
    NCBI Gene: 14385
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44308243-44314263 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband B
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    195 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316650
 protein coding gene Chr9:44308149-44314265 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034706
 protein coding gene Chr9:42882465-42888468 (+)
A/J MGP_AJ_G0034687
 protein coding gene Chr9:41685408-41690927 (+)
AKR/J MGP_AKRJ_G0034613
 protein coding gene Chr9:42547481-42553475 (+)
BALB/cJ MGP_BALBcJ_G0034678
 protein coding gene Chr9:41432746-41438755 (+)
C3H/HeJ MGP_C3HHeJ_G0034389
 protein coding gene Chr9:43005132-43011284 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035199
 protein coding gene Chr9:44156894-44162413 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032114
 protein coding gene Chr9:41265401-41270190 (+)
CAST/EiJ MGP_CASTEiJ_G0033711
 protein coding gene Chr9:42853355-42859380 (+)
CBA/J MGP_CBAJ_G0034361
 protein coding gene Chr9:45751489-45757071 (+)
DBA/2J MGP_DBA2J_G0034520
 protein coding gene Chr9:41587742-41593762 (+)
FVB/NJ MGP_FVBNJ_G0034461
 protein coding gene Chr9:40842812-40848386 (+)
LP/J MGP_LPJ_G0034601
 protein coding gene Chr9:43184859-43190845 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034505
 protein coding gene Chr9:47605654-47611507 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035220
 protein coding gene Chr9:42448809-42454664 (+)
PWK/PhJ MGP_PWKPhJ_G0033417
 protein coding gene Chr9:41462061-41466840 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033251
 protein coding gene Chr9:42771498-42777342 (+)
WSB/EiJ MGP_WSBEiJ_G0033824
 protein coding gene Chr9:42488529-42494676 (+)



Homology
more
  • Human Ortholog
    SLC37A4, solute carrier family 37 member 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC37A4, solute carrier family 37 member 4
  • Synonyms
    CDG2W, G6PT, G6PT1, G6PT2, G6PT3, GSD1b, GSD1c, GSD1d, PRO0685, SPX4, TRG-19, TRG19
  • Links
    NCBI Gene ID: 2542
    neXtProt AC: NX_O43826
    UniProt: O43826

  • Chr Location
    11q23.3; chr11:119023751-119030906 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc37a4 mouse models; 3 with human SLC37A4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit disrupted glucose homeostasis, transient neutropenia associated with impaired neutrophil trafficking and function. Mice are growth retarded and, without glucose therapy, die postnatally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    854
  • Tissues
    116
  • cDNA Data
    8
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14385 NCBI Gene Model | MGI Sequence Detail 6021 C57BL/6J ±  kb
    transcript NM_001378833 RefSeq | MGI Sequence Detail 2463 C57BL/6  
    polypeptide NP_001365758 RefSeq | MGI Sequence Detail 450 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR021159 Glycerate/sugar phosphate transporter, conserved site
      IPR011701 Major facilitator superfamily
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
      IPR051337 Organophosphate:Pi Antiporter
      IPR000849 Sugar phosphate transporter
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 8
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:3782457
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:51217 Lin B, et al., Cloning and characterization of cDNAs encoding a candidate glycogen storage disease type 1b protein in rodents. J Biol Chem. 1998 Nov 27;273(48):31656-60
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory