Prmt2 MGI Mouse Gene Detail - MGI:1316652 - protein arginine N-methyltransferase 2

Symbol

Prmt2
Name

protein arginine N-methyltransferase 2
Synonyms

Hrmt1l1

Feature Type

protein coding gene
IDs

MGI:1316652
NCBI Gene: 15468
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:76043060-76073699 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 38.74 cM
Mapping Data

6 experiments

SNPs within 2kb

1084 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1316652	protein coding gene	Chr10:76043056-76073699 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017378	protein coding gene	Chr10:76433281-76466031 (-)
A/J	MGP_AJ_G0017355	protein coding gene	Chr10:73796707-73827657 (-)
AKR/J	MGP_AKRJ_G0017316	protein coding gene	Chr10:75787894-75818560 (-)
BALB/cJ	MGP_BALBcJ_G0017315	protein coding gene	Chr10:73998929-74031431 (-)
C3H/HeJ	MGP_C3HHeJ_G0017139	protein coding gene	Chr10:75851329-75886061 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017773	protein coding gene	Chr10:79134912-79172250 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015463	protein coding gene	Chr10:70250652-70280434 (-)
CAST/EiJ	MGP_CASTEiJ_G0016709	protein coding gene	Chr10:76173948-76204234 (-)
CBA/J	MGP_CBAJ_G0017111	protein coding gene	Chr10:82233257-82266813 (-)
DBA/2J	MGP_DBA2J_G0017216	protein coding gene	Chr10:73108461-73140244 (-)
FVB/NJ	MGP_FVBNJ_G0017208	protein coding gene	Chr10:72261043-72293595 (-)
LP/J	MGP_LPJ_G0017289	protein coding gene	Chr10:76947601-76979036 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017237	protein coding gene	Chr10:84303815-84337648 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017812	protein coding gene	Chr10:75835472-75870425 (-)
PWK/PhJ	MGP_PWKPhJ_G0016493	protein coding gene	Chr10:72937528-72969047 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016276	protein coding gene	Chr10:75066532-75099994 (-)
WSB/EiJ	MGP_WSBEiJ_G0016772	protein coding gene	Chr10:75816242-75847883 (-)

Human Ortholog

PRMT2, protein arginine methyltransferase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRMT2, protein arginine methyltransferase 2
Synonyms

HRMT1L1
Links

HGNC:5186

NCBI Gene ID: 3275

neXtProt AC: NX_P55345

UniProt: P55345
Chr Location

21q22.3; chr21:46635595-46665685 (+) GRCh38

MGI Vertebrate Homology

Prmt2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRMT2
Gene Tree

Prmt2

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References

2 with disease annotations

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
46 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

11
Genomic Mutations

5 involving Prmt2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display a hyperplastic response to vascular injury while mutant mouse embryonic fibroblasts show an earlier S phase entry following release of serum starvation.

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All GO Annotations

64
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

953
Tissues

174
cDNA Data

97
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prmt2

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All Sequences

74
RefSeq

7
UniProt

6
CCDS

CCDS35942.1, CCDS78836.1

Ensembl

ENSMUSG00000020230 (Evidence)
NCBI Gene

15468

			Length	Strain/Species	Flank
genomic	15468	NCBI Gene Model \| MGI Sequence Detail	30640	C57BL/6J	± kb
transcript	NM_001302965	RefSeq \| MGI Sequence Detail	2146	ZRU/MplStud
polypeptide	Q9R144	UniProt \| EBI \| MGI Sequence Detail	448	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013253 protein arginine N-methyltransferase 2

(term hierarchy)
PDB

5FUL, 5FWA, 5FWD, 5JMQ, 8BVA, 8C1J, 8PJD
EC

2.1.1.319
InterPro Domains

IPR007848 Methyltransferase small domain

IPR025799 Protein arginine N-methyltransferase

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 113

Genomic 13

cDNA 97

Primer pair 2

Other 1

Microarray probesets 3

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MGI:1354176, MGI:2143632

Summaries

All 90

Developmental Gene Expression 11

Diseases 2

Gene Ontology 10

Phenotypes 46
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599

TSS for Prmt2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98167	Chr10:76073656-76073701 (-)	20 bp
Tssr98166	Chr10:76073623-76073630 (-)	72 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24