Bw5 QTL Detail

Summary

• Symbol
  Bw5
• Name
  body weight QTL 5

• Feature Type
  QTL
• IDs
  MGI:1316682
  NCBI Gene: 112013
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 1, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 2 alleles in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  112013

References

• Summaries
  All 3

  Phenotypes 1
• Earliest
  J:49578 Brockmann GA, et al., Quantitative trait loci affecting body weight and fatness from a mouse line selected for extreme high growth. Genetics. 1998 Sep;150(1):369-81
• Latest
  J:91835 Kaput J, et al., Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Physiol Genomics. 2004 Aug 11;18(3):316-24

Candidate Genes for Bw5:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Idh1	Chr1:65197775-65225638 (-)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 1, Idh1 (29.8 cM) showed differential expression between restricted and unrestricted diets on the A/a background. Diabesity QTLs mapping near Idh1 are Dbsty1 (21 cM),Insq2 (36 cM), Wt10q1 (25 cM), Wt6q1 (27 cM), Obq7 (28.7 cM), and Bw5 (36 cM). At another locus, Pea15 (93.8 cM) showed differential expression between restricted and unrestricted diets on the A/a background and F11r (93.3 cM) showed differential expression between A/a and A/A animals on the restricted diet. Diabesity QTL Obq9 (88.4 cM) maps near Pea15 and F11r.