Bw7 QTL Detail

Summary

• Symbol
  Bw7
• Name
  body weight QTL 7

• Feature Type
  QTL
• IDs
  MGI:1316684
  NCBI Gene: 112014
• Candidate Genes
  2 Genes

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 4, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  112014

References

• Summaries
  All 3

  Phenotypes 1
• Earliest
  J:49578 Brockmann GA, et al., Quantitative trait loci affecting body weight and fatness from a mouse line selected for extreme high growth. Genetics. 1998 Sep;150(1):369-81
• Latest
  J:91835 Kaput J, et al., Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Physiol Genomics. 2004 Aug 11;18(3):316-24

Candidate Genes for Bw7:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Cyp4a10	Chr4:115375484-115390846 (+)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 4, Cyp4a10 (49.5 cM) shows differential expression between the restricted and unrestricted diets on a A/A background while Tal1 (49.5 cM) shows differential expression between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw7 (59 cM) and Bwtq2 (55 cM) map near these candidate genes.
Tal1	Chr4:114913623-114928952 (+)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 4, Cyp4a10 (49.5 cM) shows differential expression between the restricted and unrestricted diets on a A/A background while Tal1 (49.5 cM) shows differential expression between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw7 (59 cM) and Bwtq2 (55 cM) map near these candidate genes.