Nfs1 MGI Mouse Gene Detail - MGI:1316706 - nitrogen fixation gene 1 (S. cerevisiae)

Symbol

Nfs1
Name

nitrogen fixation gene 1 (S. cerevisiae)
Synonyms

m-Nfs1

Feature Type

protein coding gene
IDs

MGI:1316706
NCBI Gene: 18041
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:155965569-155986106 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 77.34 cM
Mapping Data

2 experiments

SNPs within 2kb

580 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1316706	protein coding gene	Chr2:155965559-155986106 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026758	protein coding gene	Chr2:160980037-161006257 (-)
A/J	MGP_AJ_G0026724	protein coding gene	Chr2:154590454-154619349 (-)
AKR/J	MGP_AKRJ_G0026695	protein coding gene	Chr2:159080046-159102059 (-)
BALB/cJ	MGP_BALBcJ_G0026733	protein coding gene	Chr2:154884809-154904643 (-)
C3H/HeJ	MGP_C3HHeJ_G0026476	protein coding gene	Chr2:159440460-159461523 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027182	protein coding gene	Chr2:165714675-165736311 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024552	protein coding gene	Chr2:148087206-148104235 (-)
CAST/EiJ	MGP_CASTEiJ_G0025937	protein coding gene	Chr2:159767568-159789918 (-)
CBA/J	MGP_CBAJ_G0026453	protein coding gene	Chr2:171737569-171760842 (-)
DBA/2J	MGP_DBA2J_G0026590	protein coding gene	Chr2:153766866-153791030 (-)
FVB/NJ	MGP_FVBNJ_G0026557	protein coding gene	Chr2:152142443-152164445 (-)
LP/J	MGP_LPJ_G0026695	protein coding gene	Chr2:161119260-161140367 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026578	protein coding gene	Chr2:175682704-175708767 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027238	protein coding gene	Chr2:158953977-158976341 (-)
PWK/PhJ	MGP_PWKPhJ_G0025671	protein coding gene	Chr2:153269203-153291795 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025474	protein coding gene	Chr2:157899961-157916188 (-)
WSB/EiJ	MGP_WSBEiJ_G0026007	protein coding gene	Chr2:159843369-159865342 (-)

Human Ortholog

NFS1, NFS1 cysteine desulfurase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NFS1, NFS1 cysteine desulfurase
Synonyms

COXPD52, HUSSY-08, IscS, NIFS
Links

HGNC:15910

NCBI Gene ID: 9054

neXtProt AC: NX_Q9Y697

UniProt: Q9Y697
Chr Location

20q11.22; chr20:35668052-35699355 (-) GRCh38

MGI Vertebrate Homology

Nfs1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NFS1
Protein SuperFamily

NifS
Gene Tree

Nfs1

Diseases

1 with human NFS1 associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency 52 IDs combined oxidative phosphorylation deficiency 52 DOID:0070425 OMIM:619386

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotype references

All Mutations and Alleles

13
Endonuclease-mediated

3
Gene trapped

6
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available

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All GO Annotations

41
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

955
Tissues

178
cDNA Data

96
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nfs1

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All Sequences

75
RefSeq

9
UniProt

5
CCDS

CCDS16962.1

Ensembl

ENSMUSG00000027618 (Evidence)
NCBI Gene

18041

			Length	Strain/Species	Flank
genomic	18041	NCBI Gene Model \| MGI Sequence Detail	20538	C57BL/6J	± kb
transcript	NR_185175	RefSeq \| MGI Sequence Detail	2082	C57BL/6
polypeptide	Q9Z1J3	UniProt \| EBI \| MGI Sequence Detail	459	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000011184 cysteine desulfurase NFS1

(term hierarchy)
EC

2.8.1.7
InterPro Domains

IPR000192 Aminotransferase class V domain

IPR020578 Aminotransferase class-V, pyridoxal-phosphate binding site

IPR016454 Cysteine desulfurase

IPR010240 Cysteine desulfurase IscS

IPR015424 Pyridoxal phosphate-dependent transferase

IPR015421 Pyridoxal phosphate-dependent transferase, major domain

IPR015422 Pyridoxal phosphate-dependent transferase, small domain
GlyGen

Q9Z1J3 1 site, 1 O-linked glycan (1 site)

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All nucleic 96

cDNA 96

Microarray probesets 8

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MGI:2138826

Summaries

All 51

Developmental Gene Expression 4

Gene Ontology 16

Phenotypes 11
Earliest

J:49555 Nakai Y, et al., cDNA cloning and characterization of mouse nifS-like protein, m-Nfs1: mitochondrial localization of eukaryotic NifS-like proteins. FEBS Lett. 1998 Aug 14;433(1-2):143-8
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Nfs1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr27032	Chr2:155986058-155986112 (-)	21 bp
Tssr27031	Chr2:155977297-155977302 (-)	8,806 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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