Cox7a2 MGI Mouse Gene Detail - MGI:1316715 - cytochrome c oxidase subunit 7A2

Symbol

Cox7a2
Name

cytochrome c oxidase subunit 7A2
Synonyms

Cox7a3, COX7AL

Feature Type

protein coding gene
IDs

MGI:1316715
NCBI Gene: 12866
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:79662643-79667160 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 43.82 cM
Mapping Data

3 experiments

SNPs within 2kb

213 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1316715	protein coding gene	Chr9:79662523-79667160 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035075	protein coding gene	Chr9:80292657-80297283 (-)
A/J	MGP_AJ_G0035056	protein coding gene	Chr9:77550789-77555403 (-)
AKR/J	MGP_AKRJ_G0034984	protein coding gene	Chr9:79353431-79358049 (-)
BALB/cJ	MGP_BALBcJ_G0035044	protein coding gene	Chr9:77171914-77176526 (-)
C3H/HeJ	MGP_C3HHeJ_G0034756	protein coding gene	Chr9:79877190-79881842 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035567	protein coding gene	Chr9:82480412-82485023 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032474	protein coding gene	Chr9:76687009-76691516 (-)
CAST/EiJ	MGP_CASTEiJ_G0034074	protein coding gene	Chr9:80211135-80215612 (-)
CBA/J	MGP_CBAJ_G0034729	protein coding gene	Chr9:85413953-85422561 (-)
DBA/2J	MGP_DBA2J_G0034887	protein coding gene	Chr9:77158792-77163407 (-)
FVB/NJ	MGP_FVBNJ_G0034830	protein coding gene	Chr9:76375475-76380088 (-)
LP/J	MGP_LPJ_G0034968	protein coding gene	Chr9:80550250-80554876 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034872	protein coding gene	Chr9:86654085-86661477 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035588	protein coding gene	Chr9:79572417-79577030 (-)
PWK/PhJ	MGP_PWKPhJ_G0033778	protein coding gene	Chr9:77358855-77363682 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033614	protein coding gene	Chr9:79709539-79714145 (-)
WSB/EiJ	MGP_WSBEiJ_G0034191	protein coding gene	Chr9:79510690-79515637 (-)

Human Ortholog

COX7A2, cytochrome c oxidase subunit 7A2

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COX7A2, cytochrome c oxidase subunit 7A2
Synonyms

COX7AL, COX7AL1, COXVIIa-L, COXVIIAL, VIIAL
Links

HGNC:2288

NCBI Gene ID: 1347

neXtProt AC: NX_P14406

UniProt: P14406
Chr Location

6q14.1; chr6:75237675-75250323 (-) GRCh38

Human Ortholog

COX7A2P2, cytochrome c oxidase subunit 7A2 pseudogene 2
Synonyms

COX7A3, COX7AL, COX7AL2, COX7AP2
Links

HGNC:2290

NCBI Gene ID: 1348

UniProt: O60397
Chr Location

4q22.3; chr4:96902763-96903189 (+) GRCh38

MGI Vertebrate Homology

Cox7a2 stringent orthology
2 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: COX7A2, COX7A2P2
Gene Tree

Cox7a2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

12
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Cox7a2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

812
Tissues

106
cDNA Data

280
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cox7a2

ZFIN cox7a2a

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All Sequences

39
RefSeq

2
UniProt

1
CCDS

CCDS23366.1

Ensembl

ENSMUSG00000032330 (Evidence)
NCBI Gene

12866

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032330	Ensembl Gene Model \| MGI Sequence Detail	4518	C57BL/6J	± kb
transcript	ENSMUST00000034881	Ensembl \| MGI Sequence Detail	659	Not Applicable
polypeptide	ENSMUSP00000034881	Ensembl \| MGI Sequence Detail	83	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005787 cytochrome c oxidase subunit 7A2, mitochondrial

(term hierarchy)
PDB

8PW5, 8PW6, 8PW7
InterPro Domains

IPR039297 Cytochrome c oxidase subunit VII

IPR003177 Cytochrome c oxidase subunit VIIa, metazoa

IPR036539 Cytochrome c oxidase, subunit VIIa superfamily
GlyGen

P48771 1 site, 1 O-linked glycan (1 site)

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All nucleic 281

cDNA 280

Primer pair 1

Microarray probesets 5

Summaries

All 47

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 15
Earliest

J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
Latest

J:355679 Vercellino I, et al., SCAF1 drives the compositional diversity of mammalian respirasomes. Nat Struct Mol Biol. 2024 Jul;31(7):1061-1071

TSS for Cox7a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr90683	Chr9:79667149-79667162 (-)	4 bp
Tssr90682	Chr9:79667140-79667143 (-)	18 bp
Tssr90681	Chr9:79667131-79667138 (-)	25 bp
Tssr90680	Chr9:79667037-79667054 (-)	114 bp
Tssr90679	Chr9:79666959-79667027 (-)	167 bp
Tssr90678	Chr9:79666749-79666774 (-)	398 bp
Tssr90677	Chr9:79665649-79665654 (-)	1,508 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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