Fga Gene Detail

Summary

• Symbol
  Fga
• Name
  fibrinogen alpha chain
• Synonyms
  ENSMUSG00000059807, Fib

• Feature Type
  protein coding gene
• IDs
  MGI:1316726
  NCBI Gene: 14161
• Alliance
  gene page
• Transcription Start Sites
  43 TSS

Location &
Maps

• Sequence Map
  Chr3:82933460-82940934 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 36.96 cM, cytoband F1
• Mapping Data
  5 experiments

Strain
Comparison

• SNPs within 2kb
  313 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1316726	protein coding gene	Chr3:82933383-82940934 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027332	protein coding gene	Chr3:82849375-82856916 (+)
A/J	MGP_AJ_G0027296	protein coding gene	Chr3:80119668-80127208 (+)
AKR/J	MGP_AKRJ_G0027262	protein coding gene	Chr3:82025319-82032883 (+)
BALB/cJ	MGP_BALBcJ_G0027305	protein coding gene	Chr3:80211181-80218745 (+)
C3H/HeJ	MGP_C3HHeJ_G0027049	protein coding gene	Chr3:82311442-82318985 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027751	protein coding gene	Chr3:85967660-85975213 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025104	protein coding gene	Chr3:75839057-75846679 (+)
CAST/EiJ	MGP_CASTEiJ_G0026496	protein coding gene	Chr3:82495829-82503352 (+)
CBA/J	MGP_CBAJ_G0027024	protein coding gene	Chr3:88874018-88881534 (+)
DBA/2J	MGP_DBA2J_G0027160	protein coding gene	Chr3:79662524-79670079 (+)
FVB/NJ	MGP_FVBNJ_G0027128	protein coding gene	Chr3:77944238-77951789 (+)
LP/J	MGP_LPJ_G0027268	protein coding gene	Chr3:83836864-83844392 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027147	protein coding gene	Chr3:95265091-95272639 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027809	protein coding gene	Chr3:81820233-81827795 (+)
PWK/PhJ	MGP_PWKPhJ_G0026230	protein coding gene	Chr3:79423508-79431176 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026046	protein coding gene	Chr3:81011726-81019302 (+)
WSB/EiJ	MGP_WSBEiJ_G0026574	protein coding gene	Chr3:82155405-82162954 (+)

Homology

• Human Ortholog
  FGA, fibrinogen alpha chain

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  FGA, fibrinogen alpha chain
  
• Synonyms
  AMYLD2, Fib2
• Links
  HGNC:3661

  NCBI Gene ID: 2243

  neXtProt AC: NX_P02671

  UniProt: P02671

  
  
• Chr Location
  4q31.3; chr4:154583126-154590742 (-)  GRCh38

---

• MGI Vertebrate Homology
  Fga stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: FGA
• Gene Tree
  Fga
  

Human Diseases

• Diseases
  4 with human FGA associations

				Human Disease	Mouse Models
				brain small vessel disease IDs brain small vessel disease       DOID:0112313 OMIM:PS175780
				congenital afibrinogenemia IDs congenital afibrinogenemia       DOID:2236 MESH:D000347 NCI:C98130 OMIM:202400 UMLS_CUI:C0001733
				familial visceral amyloidosis IDs familial visceral amyloidosis       DOID:0050636 OMIM:105200 ORDO:85450
				thrombophilia IDs thrombophilia       DOID:2452 ICD10CM:D68.59 MESH:D019851 NCI:C84479 OMIM:PS188050 UMLS_CUI:C0398623

Click on a disease name to see all genes associated with that disease.

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  20 phenotypes from 1 allele in 3 genetic backgrounds
  14 phenotypes from multigenic genotypes
  85 phenotype references
  

• All Mutations and Alleles
  17
• Chemically induced (other)
  1
• Endonuclease-mediated
  8
• Radiation induced
  1
• Targeted
  5
• Transgenic
  2
• Genomic Mutations
  2 involving Fga
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  44 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for disruptions of this gene have blood that is unable to clot. On some genetic backgrounds this can lead to fatal hemorrhaging.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  49
• GO References
  10

Expression

• Assay Results
  785
• Tissues
  38
• cDNA Data
  194
• Literature Summary
  13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA FGA
  Xenbase fga
  ZFIN fga

Sequences &
Gene Models

• All Sequences
  41
• RefSeq
  4
• UniProt
  1
• CCDS
  CCDS17431.1, CCDS50939.1

• Ensembl
  ENSMUSG00000028001 (Evidence)
• NCBI Gene
  14161

Representative Sequences			Length	Strain/Species
genomic	14161	NCBI Gene Model | MGI Sequence Detail	7475	C57BL/6J
transcript	NM_010196	RefSeq | MGI Sequence Detail	3370	ZRU/MplStud
polypeptide	E9PV24	UniProt | EBI | MGI Sequence Detail	789	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000007471 fibrinogen alpha chain
  (term hierarchy)
• InterPro Domains
  IPR037579 Fibrinogen
  IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
  IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
  IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
  IPR021996 Fibrinogen alpha C domain
  IPR020837 Fibrinogen, conserved site
  IPR036056 Fibrinogen-like, C-terminal
• GlyGen
  E9PV24 2 sites, 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 198

  Genomic 1

  cDNA 194

  Primer pair 2

  Other 1

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:2139659, MGI:3642492

References

• Summaries
  All 132

  Developmental Gene Expression 13

  Diseases 1

  Gene Ontology 10

  Phenotypes 85
• Earliest
  J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
• Latest
  J:337758 Mendiola AS, et al., Defining blood-induced microglia functions in neurodegeneration through multiomic profiling. Nat Immunol. 2023 Jul;24(7):1173-1187

TSS for Fga:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29660	Chr3:82933454-82933469 (+)	2 bp
Tssr29661	Chr3:82935848-82935855 (+)	2,392 bp
Tssr29662	Chr3:82935868-82935904 (+)	2,426 bp
Tssr29663	Chr3:82935910-82935921 (+)	2,456 bp
Tssr29664	Chr3:82936384-82936404 (+)	2,934 bp
Tssr29665	Chr3:82936412-82936443 (+)	2,968 bp
Tssr29666	Chr3:82936468-82936479 (+)	3,014 bp
Tssr29667	Chr3:82936504-82936522 (+)	3,053 bp
Tssr29668	Chr3:82937505-82937516 (+)	4,051 bp
Tssr29669	Chr3:82937549-82937566 (+)	4,098 bp
Tssr29670	Chr3:82937593-82937603 (+)	4,138 bp
Tssr29671	Chr3:82938137-82938152 (+)	4,685 bp
Tssr29672	Chr3:82938240-82938245 (+)	4,783 bp
Tssr29673	Chr3:82938268-82938292 (+)	4,820 bp
Tssr29674	Chr3:82938317-82938326 (+)	4,862 bp
Tssr29675	Chr3:82938327-82938332 (+)	4,870 bp
Tssr29676	Chr3:82938337-82938346 (+)	4,882 bp
Tssr29677	Chr3:82938354-82938361 (+)	4,898 bp
Tssr29678	Chr3:82938433-82938436 (+)	4,975 bp
Tssr29679	Chr3:82938477-82938495 (+)	5,026 bp
Tssr29680	Chr3:82938500-82938519 (+)	5,050 bp
Tssr29681	Chr3:82938602-82938621 (+)	5,152 bp
Tssr29682	Chr3:82938625-82938652 (+)	5,179 bp
Tssr29683	Chr3:82938668-82938683 (+)	5,216 bp
Tssr29684	Chr3:82938693-82938722 (+)	5,248 bp
Tssr29685	Chr3:82938734-82938768 (+)	5,291 bp
Tssr29686	Chr3:82938800-82938857 (+)	5,369 bp
Tssr29687	Chr3:82938898-82938910 (+)	5,444 bp
Tssr29688	Chr3:82938922-82938935 (+)	5,469 bp
Tssr29689	Chr3:82938948-82938959 (+)	5,494 bp
Tssr29690	Chr3:82938978-82938987 (+)	5,523 bp
Tssr917	Chr3:82939005-82939008 (+)	5,547 bp
Tssr29691	Chr3:82939024-82939037 (+)	5,571 bp
Tssr29692	Chr3:82939040-82939055 (+)	5,588 bp
Tssr29693	Chr3:82939071-82939082 (+)	5,617 bp
Tssr29694	Chr3:82939104-82939128 (+)	5,656 bp
Tssr29695	Chr3:82939130-82939141 (+)	5,676 bp
Tssr29696	Chr3:82939143-82939162 (+)	5,693 bp
Tssr29697	Chr3:82939167-82939189 (+)	5,718 bp
Tssr29698	Chr3:82939304-82939339 (+)	5,862 bp
Tssr29699	Chr3:82939386-82939396 (+)	5,931 bp
Tssr29700	Chr3:82939399-82939407 (+)	5,943 bp
Tssr29701	Chr3:82939431-82939439 (+)	5,975 bp