About   Help   FAQ
Gspt1 Gene Detail
Summary
  • Symbol
    Gspt1
  • Name
    G1 to S phase transition 1
  • Synonyms
    G1st, Gst-1, Gst-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316728
    NCBI Gene: 14852
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:11037156-11072189 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 6.38 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    675 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316728
 protein coding gene Chr16:11034104-11072189 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022523
 protein coding gene Chr16:8084613-8120634 (-)
A/J MGP_AJ_G0022485
 protein coding gene Chr16:7634315-7670171 (-)
AKR/J MGP_AKRJ_G0022461
 protein coding gene Chr16:7987402-8030833 (-)
BALB/cJ MGP_BALBcJ_G0022489
 protein coding gene Chr16:7778292-7812943 (-)
C3H/HeJ MGP_C3HHeJ_G0022256
 protein coding gene Chr16:8061344-8098960 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022938
 protein coding gene Chr16:8242971-8280841 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020458
 protein coding gene Chr16:7797845-7832363 (-)
CAST/EiJ MGP_CASTEiJ_G0021783
 protein coding gene Chr16:8086332-8120269 (-)
CBA/J MGP_CBAJ_G0022225
 protein coding gene Chr16:8595760-8632631 (-)
DBA/2J MGP_DBA2J_G0022356
 protein coding gene Chr16:7639068-7673236 (-)
FVB/NJ MGP_FVBNJ_G0022332
 protein coding gene Chr16:7631672-7666116 (-)
LP/J MGP_LPJ_G0022424
 protein coding gene Chr16:8032261-8067187 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022354
 protein coding gene Chr16:8290454-8330568 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022951
 protein coding gene Chr16:7932617-7967145 (-)
PWK/PhJ MGP_PWKPhJ_G0021523
 protein coding gene Chr16:7869336-7906146 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021353
 protein coding gene Chr16:7997851-8038413 (-)
WSB/EiJ MGP_WSBEiJ_G0021831
 protein coding gene Chr16:8020071-8055943 (-)



Homology
more
  • Human Ortholog
    GSPT1, G1 to S phase transition 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSPT1, G1 to S phase transition 1
  • Synonyms
    551G9.2, eRF3a, ETF3A, GST1
  • Links
    NCBI Gene ID: 2935
    neXtProt AC: NX_P15170
    UniProt: P15170

  • Chr Location
    16p13.13; chr16:11868128-11916654 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation. In vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    24
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000062203 Ensembl Gene Model | MGI Sequence Detail 35034 C57BL/6J ±  kb
transcript ENSMUST00000080030 Ensembl | MGI Sequence Detail 2898 Not Applicable  
polypeptide ENSMUSP00000078940 Ensembl | MGI Sequence Detail 636 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000008290 eukaryotic peptide chain release factor GTP-binding subunit ERF3A
    (term hierarchy)
  • PDB
    2RQG, 2RQH
  • EC
    3.6.5.-
  • InterPro Domains
    IPR009818 Ataxin-2, C-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR005225 Small GTP-binding protein domain
    IPR000795 Translational (tr)-type GTP-binding domain
    IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    IPR004161 Translation elongation factor EFTu-like, domain 2
    IPR050100 Translation factor GTPase superfamily members
    IPR009000 Translation protein, beta-barrel domain superfamily
    IPR031157 Tr-type G domain, conserved site
  • GlyGen
    Q8R050 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 25
    cDNA 25

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-10304, MGD-MRK-9913, MGI:2146405, MGI:2146418, MGI:2146605, MGI:2146705, MGI:95605
References
more
  • Summaries
    All 46
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:10106 Hoshino S, et al., A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. EMBO J. 1989 Dec 1;8(12):3807-14
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory