Lgals7 MGI Mouse Gene Detail - MGI:1316742 - lectin, galactose binding, soluble 7

Symbol

Lgals7
Name

lectin, galactose binding, soluble 7
Synonyms

Galectin-7, Pig1

Feature Type

protein coding gene
IDs

MGI:1316742
NCBI Gene: 16858
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:28563278-28565709 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.94 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

172 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1316742	protein coding gene	Chr7:28563258-28565711 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031965	protein coding gene	Chr7:27737456-27739887 (+)
A/J	MGP_AJ_G0031943	protein coding gene	Chr7:27016411-27018842 (+)
AKR/J	MGP_AKRJ_G0031875	protein coding gene	Chr7:27714596-27717027 (+)
BALB/cJ	MGP_BALBcJ_G0031950	protein coding gene	Chr7:27173004-27175435 (+)
C3H/HeJ	MGP_C3HHeJ_G0031669	protein coding gene	Chr7:28117908-28120339 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032414	protein coding gene	Chr7:28617843-28620274 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029466	protein coding gene	Chr7:28078505-28080956 (+)
CAST/EiJ	MGP_CASTEiJ_G0031004	protein coding gene	Chr7:21414747-21417178 (+)
CBA/J	MGP_CBAJ_G0031635	protein coding gene	Chr7:29935652-29938083 (+)
DBA/2J	MGP_DBA2J_G0031787	protein coding gene	Chr7:26764830-26767261 (+)
FVB/NJ	MGP_FVBNJ_G0031744	protein coding gene	Chr7:26853637-26856067 (+)
LP/J	MGP_LPJ_G0031867	protein coding gene	Chr7:28037216-28039647 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031780	protein coding gene	Chr7:29366381-29368812 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032444	protein coding gene	Chr7:27193302-27195733 (+)
PWK/PhJ	MGP_PWKPhJ_G0030729	protein coding gene	Chr7:21802189-21804620 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030562	protein coding gene	Chr7:18214442-18216867 (+)
WSB/EiJ	MGP_WSBEiJ_G0031113	protein coding gene	Chr7:27570522-27572952 (+)

Human Ortholog

LGALS7, galectin 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LGALS7, galectin 7
Synonyms

GAL7, LGALS7A
Links

HGNC:6568

NCBI Gene ID: 3963

neXtProt AC: NX_P47929
Chr Location

19q13.2

Human Ortholog

LGALS7B, galectin 7B
Synonyms

Gal-7, GAL7, HKL-14, LGALS7, PI7
Links

HGNC:34447

NCBI Gene ID: 653499

neXtProt AC: NX_P47929

UniProt: P47929
Chr Location

19q13.2

MGI Vertebrate Homology

Lgals7 stringent orthology
2 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LGALS7, LGALS7B
Gene Tree

Lgals7

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

1
Gene trapped

6
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased sensitivity to skin UVB irradiation with increased apoptosis and proliferation, and delayed wound healing due to reduced cell migration.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

4
cDNA Data

10
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

43
RefSeq

4
UniProt

4
CCDS

CCDS21060.1

Ensembl

ENSMUSG00000053522 (Evidence)
NCBI Gene

16858

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053522	Ensembl Gene Model \| MGI Sequence Detail	2432	C57BL/6J	± kb
transcript	ENSMUST00000138272	Ensembl \| MGI Sequence Detail	657	Not Applicable
polypeptide	ENSMUSP00000123110	Ensembl \| MGI Sequence Detail	136	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009774 galectin-7

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR001079 Galectin, carbohydrate recognition domain

IPR044156 Galectin-like

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All nucleic 13

cDNA 10

Primer pair 2

Other 1

Microarray probesets 4

Summaries

All 50

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 13
Earliest

J:49734 Magnaldo T, et al., Galectin-7, a marker of all types of stratified epithelia. Differentiation. 1998 Jul;63(3):159-68
Latest

J:346445 Wu G, et al., Galectin 7 leads to a relative reduction in CD4+ T cells, mediated by PD-1. Sci Rep. 2024 Mar 19;14(1):6625

TSS for Lgals7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65574	Chr7:28563256-28563260 (+)	-20 bp
Tssr65575	Chr7:28563870-28563885 (+)	600 bp
Tssr65576	Chr7:28565649-28565680 (+)	2,387 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24