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Ptprt Gene Detail
Summary
  • Symbol
    Ptprt
  • Name
    protein tyrosine phosphatase receptor type T
  • Synonyms
    RPTPrho
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321152
    NCBI Gene: 19281
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:161363910-162503067 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 81.91 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    31889 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321152
 protein coding gene Chr2:161363908-162503106 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026811
 protein coding gene Chr2:166752501-167928962 (-)
A/J MGP_AJ_G0026777
 protein coding gene Chr2:160061346-161178416 (-)
AKR/J MGP_AKRJ_G0026748
 protein coding gene Chr2:164799044-165935175 (-)
BALB/cJ MGP_BALBcJ_G0026786
 protein coding gene Chr2:160386229-161509801 (-)
C3H/HeJ MGP_C3HHeJ_G0026528
 protein coding gene Chr2:165130902-166297379 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027235
 protein coding gene Chr2:171684962-172873501 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024605
 protein coding gene Chr2:153410718-154494554 (-)
CAST/EiJ MGP_CASTEiJ_G0025990
 protein coding gene Chr2:165504163-166659473 (-)
CBA/J MGP_CBAJ_G0026505
 protein coding gene Chr2:177883341-179107853 (-)
DBA/2J MGP_DBA2J_G0026643
 protein coding gene Chr2:159234398-160366399 (-)
FVB/NJ MGP_FVBNJ_G0026610
 protein coding gene Chr2:157624836-158735707 (-)
LP/J MGP_LPJ_G0026746
 protein coding gene Chr2:166862775-168059651 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026631
 protein coding gene Chr2:181587214-182808674 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027291
 protein coding gene Chr2:164643673-165808720 (-)
PWK/PhJ MGP_PWKPhJ_G0025724
 protein coding gene Chr2:158788380-159900774 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025527
 protein coding gene Chr2:163526491-164682241 (-)
WSB/EiJ MGP_WSBEiJ_G0026060
 protein coding gene Chr2:165521908-166686682 (-)



Homology
more
  • Human Ortholog
    PTPRT, protein tyrosine phosphatase receptor type T
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPRT, protein tyrosine phosphatase receptor type T
  • Synonyms
    RPTP-rho, RPTPrho, R-PTP-T
  • Links
    NCBI Gene ID: 11122
    neXtProt AC: NX_O14522
    UniProt: O14522

  • Chr Location
    20q12-q13.11; chr20:42031890-43189970 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PTPRT associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are highly susceptible to carcinogen azoxymethane-induced colon tumors. Mice homozygous for another null allele exhibit depression-like behaviors associated with dysregulated synaptic functions and neurogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    914
  • Tissues
    138
  • cDNA Data
    9
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053141 Ensembl Gene Model | MGI Sequence Detail 1139158 C57BL/6J ±  kb
    transcript ENSMUST00000109441 Ensembl | MGI Sequence Detail 6623 Not Applicable  
    polypeptide ENSMUSP00000105067 Ensembl | MGI Sequence Detail 1455 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000013480 receptor-type tyrosine-protein phosphatase T
      (term hierarchy)
    • EC
      3.1.3.48
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR000998 MAM domain
      IPR050348 Protein-Tyrosine Phosphatase
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR029021 Protein-tyrosine phosphatase-like
      IPR051622 Receptor-type Tyrosine-protein Phosphatases
      IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
      IPR000387 Tyrosine-specific protein phosphatases domain
    • GlyGen
      Q99M80 12 sites, 7 N-linked glycans (7 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 10
      Primer pair 1
      Other 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 11
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:39565 McAndrew PE, et al., Identification and characterization of RPTPrho, a novel RPTPmu/kappa like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system. Brain Res Mol Brain Res. 1998 May;56(1-2):9-21
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory