Ppp2ca MGI Mouse Gene Detail - MGI:1321159 - protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform

Symbol

Ppp2ca
Name

protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
Synonyms

PP2A

Feature Type

protein coding gene
IDs

MGI:1321159
NCBI Gene: 19052
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:51989651-52013576 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 31.86 cM
Mapping Data

3 experiments

SNPs within 2kb

531 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1321159	protein coding gene	Chr11:51989508-52018605 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018281	protein coding gene	Chr11:51396460-51425107 (+)
A/J	MGP_AJ_G0018250	protein coding gene	Chr11:49439729-49469883 (+)
AKR/J	MGP_AKRJ_G0018220	protein coding gene	Chr11:51003336-51035705 (+)
BALB/cJ	MGP_BALBcJ_G0018221	protein coding gene	Chr11:49739604-49768552 (+)
C3H/HeJ	MGP_C3HHeJ_G0018032	protein coding gene	Chr11:51034546-51064643 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018671	protein coding gene	Chr11:52929213-52959924 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016323	protein coding gene	Chr11:46990678-47020636 (+)
CAST/EiJ	MGP_CASTEiJ_G0017597	protein coding gene	Chr11:51038618-51072916 (+)
CBA/J	MGP_CBAJ_G0018007	protein coding gene	Chr11:55429336-55458239 (+)
DBA/2J	MGP_DBA2J_G0018114	protein coding gene	Chr11:49146026-49177323 (+)
FVB/NJ	MGP_FVBNJ_G0018109	protein coding gene	Chr11:48868193-48896815 (+)
LP/J	MGP_LPJ_G0018190	protein coding gene	Chr11:51803777-51833462 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018132	protein coding gene	Chr11:56811125-56840703 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018714	protein coding gene	Chr11:51100318-51130123 (+)
PWK/PhJ	MGP_PWKPhJ_G0017372	protein coding gene	Chr11:49675082-49706665 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017167	protein coding gene	Chr11:50833115-50866729 (+)
WSB/EiJ	MGP_WSBEiJ_G0017644	protein coding gene	Chr11:50745022-50775675 (+)

Human Ortholog

PPP2CA, protein phosphatase 2 catalytic subunit alpha

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP2CA, protein phosphatase 2 catalytic subunit alpha
Synonyms

HJS3, NEDLBA, PP2Ac, PP2CA, PP2Calpha, RP-C
Links

HGNC:9299

NCBI Gene ID: 5515

neXtProt AC: NX_P67775

UniProt: P67775
Chr Location

5q31.1; chr5:134194035-134226073 (-) GRCh38

MGI Vertebrate Homology

Ppp2ca stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: PPP2CA
Gene Tree

Ppp2ca

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Phenotype Summary

35 phenotypes from 6 alleles in 6 genetic backgrounds
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

14
Targeted

8
Transgenic

1
Genomic Mutations

1 involving Ppp2ca
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null embryos die before gastrulation and exhibit widespread degeneration. Mesoderm is not formed.

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All GO Annotations

92
GO References

30

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

885
Tissues

130
cDNA Data

10
Literature Summary

24

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp2ca

ZFIN ppp2caa, ppp2cab

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All Sequences

41
RefSeq

2
UniProt

1
CCDS

CCDS24666.1

Ensembl

ENSMUSG00000020349 (Evidence)
NCBI Gene

19052

			Length	Strain/Species	Flank
genomic	19052	NCBI Gene Model \| MGI Sequence Detail	23926	C57BL/6J	± kb
transcript	NM_019411	RefSeq \| MGI Sequence Detail	1930	C57BL/6
polypeptide	P63330	UniProt \| EBI \| MGI Sequence Detail	309	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003211 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

(term hierarchy)
EC

3.1.3.16
InterPro Domains

IPR004843 Calcineurin-like phosphoesterase domain, ApaH type

IPR029052 Metallo-dependent phosphatase-like

IPR047129 Serine/Threonine protein phosphatase PP2A-like

IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
GlyGen

P63330 1 site, 1 O-linked glycan (1 site)

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All nucleic 18

Genomic 2

cDNA 10

Primer pair 4

Other 2

Microarray probesets 4

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MGI:2144711

Summaries

All 160

Developmental Gene Expression 24

Gene Ontology 30

Phenotypes 28
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:355261 Rehmani T, et al., SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP. Life Sci Alliance. 2024 Dec;7(12)

TSS for Ppp2ca:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101308	Chr11:51989612-51989623 (+)	-33 bp
Tssr101309	Chr11:51989629-51989640 (+)	-16 bp
Tssr101310	Chr11:51989642-51989669 (+)	5 bp
Tssr101311	Chr11:51989679-51989702 (+)	40 bp
Tssr101312	Chr11:52008824-52008837 (+)	19,180 bp
Tssr101313	Chr11:52011741-52011748 (+)	22,094 bp
Tssr101314	Chr11:52012729-52012784 (+)	23,106 bp
Tssr101315	Chr11:52013090-52013106 (+)	23,447 bp
Tssr101316	Chr11:52013244-52013259 (+)	23,601 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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