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Ppp2cb Gene Detail
Summary
  • Symbol
    Ppp2cb
  • Name
    protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
  • Synonyms
    D8Ertd766e, PP2Ac
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321161
    NCBI Gene: 19053
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:34089653-34109469 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 20.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    571 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321161
 protein coding gene Chr8:34089653-34109831 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033524
 protein coding gene Chr8:32056973-32076823 (+)
A/J MGP_AJ_G0033504
 protein coding gene Chr8:30828191-30848009 (+)
AKR/J MGP_AKRJ_G0033428
 protein coding gene Chr8:31790292-31811015 (+)
BALB/cJ MGP_BALBcJ_G0033500
 protein coding gene Chr8:30950164-30970382 (+)
C3H/HeJ MGP_C3HHeJ_G0033212
 protein coding gene Chr8:32120047-32140009 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034016
 protein coding gene Chr8:33290206-33310344 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030965
 protein coding gene Chr8:27633700-27654417 (+)
CAST/EiJ MGP_CASTEiJ_G0032539
 protein coding gene Chr8:31542602-31564285 (+)
CBA/J MGP_CBAJ_G0033190
 protein coding gene Chr8:34602247-34622216 (+)
DBA/2J MGP_DBA2J_G0033343
 protein coding gene Chr8:30811707-30831748 (+)
FVB/NJ MGP_FVBNJ_G0033288
 protein coding gene Chr8:30471606-30491983 (+)
LP/J MGP_LPJ_G0033433
 protein coding gene Chr8:32011733-32031792 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033330
 protein coding gene Chr8:34129414-34151662 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034035
 protein coding gene Chr8:31872199-31894786 (+)
PWK/PhJ MGP_PWKPhJ_G0032251
 protein coding gene Chr8:30325832-30346253 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032082
 protein coding gene Chr8:31153120-31175900 (+)
WSB/EiJ MGP_WSBEiJ_G0032655
 protein coding gene Chr8:32015172-32036117 (+)



Homology
more
  • Human Ortholog
    PPP2CB, protein phosphatase 2 catalytic subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP2CB, protein phosphatase 2 catalytic subunit beta
  • Synonyms
    PP2Abeta, PP2CB
  • Links
    NCBI Gene ID: 5516
    neXtProt AC: NX_P62714
    UniProt: P62714

  • Chr Location
    8p12; chr8:30774457-30814314 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    85
  • cDNA Data
    13
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009630 Ensembl Gene Model | MGI Sequence Detail 19817 C57BL/6J ±  kb
    transcript ENSMUST00000009774 Ensembl | MGI Sequence Detail 1469 Not Applicable  
    polypeptide ENSMUSP00000009774 Ensembl | MGI Sequence Detail 309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000003210 serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
      (term hierarchy)
    • EC
      3.1.3.16
    • InterPro Domains
      IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
      IPR029052 Metallo-dependent phosphatase-like
      IPR047129 Serine/Threonine protein phosphatase PP2A-like
      IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
    • GlyGen
      P62715 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 14
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1289237, MGI:2142462
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 19
      Gene Ontology 12
      Phenotypes 14
    • Earliest
      J:57652 Becker W, et al., Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain. J Biol Chem. 1994 Sep 9;269(36):22586-92
    • Latest
      J:346063 Rehmani T, et al., Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3 (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of Myocardium without Affecting Hippo Pathway. Int J Mol Sci. 2024 Mar 1;25(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory