Ccnt1 MGI Mouse Gene Detail - MGI:1328363

Symbol

Ccnt1
Name

cyclin T1
Synonyms

2810478G24Rik, CycT1

Feature Type

protein coding gene
IDs

MGI:1328363
NCBI Gene: 12455
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr15:98436570-98468340 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 54.54 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

844 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1328363	protein coding gene	Chr15:98436570-98468804 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022301	protein coding gene	Chr15:100271889-100307276 (-)
A/J	MGP_AJ_G0022259	protein coding gene	Chr15:96318050-96350353 (-)
AKR/J	MGP_AKRJ_G0022234	protein coding gene	Chr15:99274572-99320618 (-)
BALB/cJ	MGP_BALBcJ_G0022266	protein coding gene	Chr15:96514148-96547600 (-)
C3H/HeJ	MGP_C3HHeJ_G0022034	protein coding gene	Chr15:99323763-99355787 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022711	protein coding gene	Chr15:103983168-104015942 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020236	protein coding gene	Chr15:92233837-92270327 (-)
CAST/EiJ	MGP_CASTEiJ_G0021557	protein coding gene	Chr15:100178375-100213882 (-)
CBA/J	MGP_CBAJ_G0022003	protein coding gene	Chr15:107515808-107553317 (-)
DBA/2J	MGP_DBA2J_G0022129	protein coding gene	Chr15:95763849-95796687 (-)
FVB/NJ	MGP_FVBNJ_G0022109	protein coding gene	Chr15:94736629-94768706 (-)
LP/J	MGP_LPJ_G0022201	protein coding gene	Chr15:100425747-100459385 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022129	protein coding gene	Chr15:111538449-111573930 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022726	protein coding gene	Chr15:99361570-99393893 (-)
PWK/PhJ	MGP_PWKPhJ_G0021298	protein coding gene	Chr15:95880182-95913937 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021133	protein coding gene	Chr15:99202561-99235908 (-)
WSB/EiJ	MGP_WSBEiJ_G0021607	protein coding gene	Chr15:99892174-99940076 (-)

Human Ortholog

CCNT1, cyclin T1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCNT1, cyclin T1
Synonyms

CCNT, CYCT1, HIVE1
Links

HGNC:1599

NCBI Gene ID: 904

neXtProt AC: NX_O60563

UniProt: O60563
Chr Location

12q13.11-q13.12; chr12:48688458-48716998 (-) GRCh38

MGI Vertebrate Homology

Ccnt1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCNT1
Gene Tree

Ccnt1

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References

1 with disease annotations

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

14
Radiation induced

2
Targeted

1
Genomic Mutations

3 involving Ccnt1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a hypomorphic allele do not express AIRE-responsive genes in the thymus and display lymphocytic infiltration of lacrimal and salivary glands.

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All GO Annotations

44
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

795
Tissues

66
cDNA Data

17
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ccnt1

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All Sequences

58
RefSeq

7
UniProt

2
CCDS

CCDS27797.1

Ensembl

ENSMUSG00000011960 (Evidence)
NCBI Gene

12455

			Length	Strain/Species	Flank
genomic	12455	NCBI Gene Model \| MGI Sequence Detail	31771	C57BL/6J	± kb
transcript	NM_009833	RefSeq \| MGI Sequence Detail	6796	C57BL/6
polypeptide	Q9QWV9	UniProt \| EBI \| MGI Sequence Detail	724	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005139 cyclin-T1

(term hierarchy)
InterPro Domains

IPR043198 Cyclin/Cyclin-like subunit Ssn8

IPR013763 Cyclin-like domain

IPR036915 Cyclin-like superfamily

IPR006671 Cyclin, N-terminal

IPR047320 Cyclin-T1, second cyclin box

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All nucleic 17

cDNA 17

Microarray probesets 5

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MGI:1920080, MGI:2145948

Summaries

All 86

Developmental Gene Expression 7

Diseases 1

Gene Ontology 12

Phenotypes 33
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ccnt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136252	Chr15:98465643-98465657 (-)	2,690 bp
Tssr136251	Chr15:98465511-98465629 (-)	2,770 bp
Tssr136250	Chr15:98465470-98465501 (-)	2,854 bp
Tssr136249	Chr15:98465443-98465454 (-)	2,891 bp
Tssr136248	Chr15:98465390-98465397 (-)	2,946 bp
Tssr136247	Chr15:98462319-98462323 (-)	6,019 bp
Tssr136246	Chr15:98441853-98441870 (-)	26,478 bp
Tssr136245	Chr15:98441788-98441805 (-)	26,543 bp
Tssr136244	Chr15:98440502-98440506 (-)	27,836 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24