Fmod MGI Mouse Gene Detail - MGI:1328364

Symbol

Fmod
Name

fibromodulin
Synonyms

SLRR2E

Feature Type

protein coding gene
IDs

MGI:1328364
NCBI Gene: 14264
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr1:133964992-133976015 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 58.09 cM
Mapping Data

3 experiments

SNPs within 2kb

417 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1328364	protein coding gene	Chr1:133964992-133976018 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016496	protein coding gene	Chr1:137671718-137684248 (+)
A/J	MGP_AJ_G0016479	protein coding gene	Chr1:132501823-132512816 (+)
AKR/J	MGP_AKRJ_G0016444	protein coding gene	Chr1:136456862-136467836 (+)
BALB/cJ	MGP_BALBcJ_G0016439	protein coding gene	Chr1:132831756-132845434 (+)
C3H/HeJ	MGP_C3HHeJ_G0016265	protein coding gene	Chr1:136549611-136560591 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016900	protein coding gene	Chr1:142699211-142715887 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014611	protein coding gene	Chr1:125645714-125656744 (+)
CAST/EiJ	MGP_CASTEiJ_G0015845	protein coding gene	Chr1:135595111-135610893 (+)
CBA/J	MGP_CBAJ_G0016238	protein coding gene	Chr1:147607731-147622383 (+)
DBA/2J	MGP_DBA2J_G0016344	protein coding gene	Chr1:131513775-131524784 (+)
FVB/NJ	MGP_FVBNJ_G0016343	protein coding gene	Chr1:130135937-130146889 (+)
LP/J	MGP_LPJ_G0016415	protein coding gene	Chr1:138946533-138957649 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016368	protein coding gene	Chr1:153343333-153355518 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016936	protein coding gene	Chr1:136171682-136184257 (+)
PWK/PhJ	MGP_PWKPhJ_G0015631	protein coding gene	Chr1:130528221-130539387 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015418	protein coding gene	Chr1:135148978-135159994 (+)
WSB/EiJ	MGP_WSBEiJ_G0015908	protein coding gene	Chr1:136203316-136214232 (+)

Human Ortholog

FMOD, fibromodulin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FMOD, fibromodulin
Synonyms

FM, SLRR2E
Links

HGNC:3774

NCBI Gene ID: 2331

neXtProt AC: NX_Q06828

UniProt: Q06828
Chr Location

1q32.1; chr1:203340628-203351758 (-) GRCh38

MGI Vertebrate Homology

Fmod stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FMOD
Gene Tree

Fmod

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Mutations/Alleles

1 with disease annotations

References

3 with disease annotations

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Phenotype Summary

9 phenotypes from 1 allele in 2 genetic backgrounds
31 phenotypes from multigenic genotypes
5 images
47 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Targeted

4
Genomic Mutations

3 involving Fmod
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null mutation contain more immature, small diameter collagen fibrils in the tendon and display an increase in age-dependent osteoarthritis and degenerative changes of the articular cartilage.

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All GO Annotations

4
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1315
Tissues

138
cDNA Data

107
Literature Summary

32

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN fmoda, fmodb

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All Sequences

44
RefSeq

2
UniProt

5
CCDS

CCDS15301.1

Ensembl

ENSMUSG00000041559 (Evidence)
NCBI Gene

14264

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041559	Ensembl Gene Model \| MGI Sequence Detail	11024	C57BL/6J	± kb
transcript	ENSMUST00000048183	Ensembl \| MGI Sequence Detail	3120	Not Applicable
polypeptide	ENSMUSP00000035489	Ensembl \| MGI Sequence Detail	376	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007579 fibromodulin

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR000372 Leucine-rich repeat N-terminal domain

IPR003591 Leucine-rich repeat, typical subtype

IPR050333 Small Leucine-Rich Proteoglycans
GlyGen

P50608 5 sites, 3 N-linked glycans (3 sites)

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All nucleic 112

Genomic 2

cDNA 107

Primer pair 3

Microarray probesets 4

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MGI:2138163, MGI:2138492

Summaries

All 108

Developmental Gene Expression 32

Diseases 3

Gene Ontology 3

Phenotypes 47
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:336100 Brutsch SM, et al., Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome. Cell Mol Life Sci. 2023 Mar 15;80(4):89

TSS for Fmod:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8829	Chr1:133965201-133965222 (+)	220 bp
Tssr8830	Chr1:133965228-133965268 (+)	256 bp
Tssr8831	Chr1:133965272-133965290 (+)	289 bp
Tssr8832	Chr1:133967966-133967977 (+)	2,980 bp
Tssr8833	Chr1:133967990-133968000 (+)	3,003 bp
Tssr8834	Chr1:133968012-133968017 (+)	3,023 bp
Tssr216	Chr1:133968039-133968046 (+)	3,051 bp
Tssr8835	Chr1:133968063-133968069 (+)	3,074 bp
Tssr8836	Chr1:133968077-133968098 (+)	3,096 bp
Tssr8837	Chr1:133968110-133968120 (+)	3,123 bp
Tssr8838	Chr1:133968138-133968144 (+)	3,149 bp
Tssr8839	Chr1:133968157-133968168 (+)	3,171 bp
Tssr8840	Chr1:133968198-133968218 (+)	3,216 bp
Tssr8841	Chr1:133968476-133968492 (+)	3,492 bp
Tssr8842	Chr1:133968552-133968576 (+)	3,572 bp
Tssr8843	Chr1:133968607-133968633 (+)	3,628 bp
Tssr8844	Chr1:133968667-133968678 (+)	3,681 bp
Tssr8845	Chr1:133974416-133974436 (+)	9,434 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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