Cdk9 MGI Mouse Gene Detail - MGI:1328368 - cyclin dependent kinase 9

Symbol

Cdk9
Name

cyclin dependent kinase 9
Synonyms

PITALRE

Feature Type

protein coding gene
IDs

MGI:1328368
NCBI Gene: 107951
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr2:32595796-32603088 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 22.09 cM
Mapping Data

1 experiment

SNPs within 2kb

225 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1328368	protein coding gene	Chr2:32595794-32608098 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025618	protein coding gene	Chr2:31189423-31199674 (-)
A/J	MGP_AJ_G0025595	protein coding gene	Chr2:29857966-29865937 (-)
AKR/J	MGP_AKRJ_G0025565	protein coding gene	Chr2:30930430-30938464 (-)
BALB/cJ	MGP_BALBcJ_G0025592	protein coding gene	Chr2:29978955-29986778 (-)
C3H/HeJ	MGP_C3HHeJ_G0025352	protein coding gene	Chr2:30810355-30821046 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026036	protein coding gene	Chr2:32130300-32137710 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023445	protein coding gene	Chr2:28579387-28586901 (-)
CAST/EiJ	MGP_CASTEiJ_G0024814	protein coding gene	Chr2:30758776-30769898 (-)
CBA/J	MGP_CBAJ_G0025330	protein coding gene	Chr2:33360537-33368035 (-)
DBA/2J	MGP_DBA2J_G0025463	protein coding gene	Chr2:29624444-29631317 (-)
FVB/NJ	MGP_FVBNJ_G0025425	protein coding gene	Chr2:29504491-29517768 (-)
LP/J	MGP_LPJ_G0025549	protein coding gene	Chr2:31062509-31070695 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025456	protein coding gene	Chr2:32980728-32990036 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026094	protein coding gene	Chr2:30800891-30808180 (-)
PWK/PhJ	MGP_PWKPhJ_G0024562	protein coding gene	Chr2:29529612-29536944 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024362	protein coding gene	Chr2:30958178-30965435 (-)
WSB/EiJ	MGP_WSBEiJ_G0024883	protein coding gene	Chr2:30980437-30989526 (-)

Human Ortholog

CDK9, cyclin dependent kinase 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDK9, cyclin dependent kinase 9
Synonyms

C-2k, CDC2L4, CTK1, PITALRE, TAK
Links

HGNC:1780

NCBI Gene ID: 1025

neXtProt AC: NX_P50750

UniProt: P50750
Chr Location

9q34.11; chr9:127785679-127790792 (+) GRCh38

MGI Vertebrate Homology

Cdk9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDK9
Gene Tree

Cdk9

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Phenotype Summary

6 phenotypes from 1 allele in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

1
Gene trapped

5
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

90
GO References

27

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

946
Tissues

92
cDNA Data

132
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDK9

Xenbase cdk9

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All Sequences

57
RefSeq

4
UniProt

4
CCDS

CCDS15927.1

Ensembl

ENSMUSG00000009555 (Evidence)
NCBI Gene

107951

			Length	Strain/Species	Flank
genomic	ENSMUSG00000009555	Ensembl Gene Model \| MGI Sequence Detail	7293	C57BL/6J	± kb
transcript	ENSMUST00000009699	Ensembl \| MGI Sequence Detail	1733	Not Applicable
polypeptide	ENSMUSP00000009699	Ensembl \| MGI Sequence Detail	372	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005267 cyclin-dependent kinase 9

(term hierarchy)
EC

2.7.11.22, 2.7.11.23
InterPro Domains

IPR050108 Cyclin-dependent kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 133

cDNA 132

Primer pair 1

Microarray probesets 4

Summaries

All 84

Developmental Gene Expression 10

Gene Ontology 27

Phenotypes 13
Earliest

J:50128 Bagella L, et al., Cloning of murine CDK9/PITALRE and its tissue-specific expression in development. J Cell Physiol. 1998 Nov;177(2):206-13
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cdk9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr23542	Chr2:32604964-32604969 (-)	-1,879 bp
Tssr23541	Chr2:32604935-32604954 (-)	-1,857 bp
Tssr23540	Chr2:32604498-32604537 (-)	-1,430 bp
Tssr23539	Chr2:32603565-32603589 (-)	-489 bp
Tssr23538	Chr2:32603232-32603263 (-)	-160 bp
Tssr23537	Chr2:32603077-32603103 (-)	-2 bp
Tssr23536	Chr2:32603054-32603074 (-)	24 bp
Tssr23535	Chr2:32602740-32602805 (-)	315 bp
Tssr23534	Chr2:32602246-32602288 (-)	821 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24